The Western diet is a modern dietary pattern characterized by high intakes of pre-packaged
foods, refined grains, red meat, processed meat, high-sugar drinks, candy, sweets, fried …

Abstract Type 2 diabetes (T2D), which has currently become a global pandemic, is a
metabolic disease largely characterised by impaired insulin secretion and action. Significant …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Biological energy transduction underlies all physiological phenomena in cells. The
metabolic systems that support energy transduction have been of great interest due to their …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

The majority of human energy metabolism occurs in skeletal muscle mitochondria
emphasizing the importance of understanding the regulation of myocellular mitochondrial …

Despite growing interest and a recent surge in papers, the role of autophagy in glucose and
lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of …

Both the consumption of a diet rich in fatty acids and exercise training result in similar
adaptations in several skeletal muscle proteins. These adaptations are involved in fatty acid …