The potential of genetics in identifying women at lower risk of breast cancer

A Bolze, ET Cirulli, C Hajek, JMS Blitstein… - JAMA …, 2024 - jamanetwork.com
Importance Genetic information is not being used to identify women at lower risk of breast
cancer or other diseases in clinical practice. With the new US Preventive Services Task …

Screening Familial Risk for Hereditary Breast and Ovarian Cancer

D Kiser, G Elhanan, A Bolze, I Neveux… - JAMA Network …, 2024 - jamanetwork.com
Importance Most patients with pathogenic or likely pathogenic (P/LP) variants for breast
cancer have not undergone genetic testing. Objective To identify patients meeting family …

[PDF][PDF] Implementing the Risk Stratification and Clinical Management of Breast Cancer Families Using Polygenic Risk Score Evaluation: A Pilot Study

B Rizzacasa, V Nicolì, C Tancredi… - Journal of …, 2024 - researchgate.net
Background: The identification of women at high risk of breast cancer (BC) is crucial for
personalized screening strategies. Pathogenic and likely pathogenic variants (PVs/LPVs) in …

The Metabolic Role of MAP3K15: Genetic and Phenotypic Insights from the 23andMe Research Database and Genetics-Driven Recruitment

JJ Brady, K Kalkus, DT Nguyen, J Wen, ZL Fuller, Y Qi… - medRxiv, 2024 - medrxiv.org
MAP3K15 has been previously associated with protection from type 2 diabetes (T2D),
prompting interest in the development of MAP3K15 inhibitors as a potential therapeutic …