Liver cancer represents a major health problem worldwide with growing incidence and high
mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely …

The liver is not oblivious to the passage of time, as ageing is a major risk factor for the
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …

Liver fibrosis is characterized by the activation of perivascular hepatic stellate cells (HSCs),
the release of fibrogenic nanosized extracellular vesicles (EVs), and increased HSC …

Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer-related
mortality worldwide. Nop2/Sun domain family member 5 (NSUN5), a conserved RNA 5 …

Liver cancer is a major global health concern, ranking among the top causes of cancer-
related deaths worldwide. Despite advances in medical research, the prognosis for liver …

Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited
therapeutic options and poor prognosis. In recent years, immunotherapies such as immune …

Metabolic dysfunction-associated steatotic (fatty) liver disease (MASLD), previously termed
non-alcoholic fatty liver disease, is a worldwide epidemic that can lead to hepatic …

Background & Aims Hepatic stellate cells (HSCs) are the key drivers of fibrosis in metabolic
dysfunction-associated steatohepatitis (MASH), the fastest growing cause of hepatocellular …

Over the last decade, epidermal growth factor receptor (EGFR)-targeted therapies have
transformed the treatment landscape for patients with advanced solid tumors. Despite these …

Liver fibrosis is a pathophysiologic manifestation of chronic liver disease and a precursor to
cirrhosis and hepatocellular carcinoma. Glycolysis provides intermediate metabolites as well …