Neuroprotective effect of antioxidants in the brain

KH Lee, M Cha, BH Lee - International journal of molecular sciences, 2020 - mdpi.com
The brain is vulnerable to excessive oxidative insults because of its abundant lipid content,
high energy requirements, and weak antioxidant capacity. Reactive oxygen species (ROS) …

Pharmacological inhibition of ferroptosis as a therapeutic target for neurodegenerative diseases and strokes

Y Wang, S Wu, Q Li, H Sun, H Wang - Advanced Science, 2023 - Wiley Online Library
Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

[HTML][HTML] Supplementation with selenium attenuates autism-like behaviors and improves oxidative stress, inflammation and related gene expression in an autism …

H Wu, G Zhao, S Liu, Q Zhang, P Wang, Y Cao… - The Journal of Nutritional …, 2022 - Elsevier
Autism spectrum disorder (ASD) refers to a group of neurodevelopmental disorders. The
etiology and pathological mechanisms of ASD are still unknown, and its prognosis is poor …

Non-enzymatic antioxidants against Alzheimer's disease: prevention, diagnosis and therapy

A Varesi, LIM Campagnoli, A Carrara, I Pola, E Floris… - Antioxidants, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …

Insight into the emerging and common experimental in-vivo models of Alzheimer's disease

R Dhapola, S Kumari, P Sharma… - Laboratory Animal …, 2023 - Springer
Alzheimer's disease (AD) is a multifactorial, rapidly progressing neurodegenerative disorder.
As the exact cause of the disease is still unclear, the drug development is very challenging …

Alzheimer's disease association with metals and metalloids concentration in blood and urine

L Strumylaite, R Kregzdyte, O Kucikiene… - International Journal of …, 2022 - mdpi.com
As there is some evidence that the risk for Alzheimer's disease (AD) is partially attributable to
environmental exposure to some metals and metalloids, we examined an association …

The zinc-sensing receptor GPR39 in physiology and as a pharmacological target

A Laitakari, L Liu, TM Frimurer, B Holst - International Journal of …, 2021 - mdpi.com
The G-protein coupled receptor GPR39 is abundantly expressed in various tissues and can
be activated by changes in extracellular Zn2+ in physiological concentrations. Previously …

Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury

SP Navabi, F Badreh, MK Shooshtari, S Hajipour… - Heliyon, 2024 - cell.com
Traumatic brain injury (TBI) is one of the most causes of death and disability among people,
leading to a wide range of neurological deficits. The important process of neurogenesis in …

Potential effects of melatonin and micronutrients on mitochondrial dysfunction during a cytokine storm typical of oxidative/inflammatory diseases

VM Martín Giménez, N de Las Heras, L Ferder… - Diseases, 2021 - mdpi.com
Exaggerated oxidative stress and hyper-inflammation are essential features of
oxidative/inflammatory diseases. Simultaneously, both processes may be the cause or …

Association of Dietary Intake of Zinc and Selenium with Breast Cancer Risk: A Case-Control Study in Chinese Women

K Tu, K Liu, Y Wang, Y Jiang, C Zhang - Nutrients, 2023 - mdpi.com
As major nonenzymatic antioxidant components in the body, dietary Zinc (Zn) and Selenium
(Se) may have an impact on breast cancer development. This study aimed to investigate the …