In vivo response to polypropylene following implantation in animal models: a review of biocompatibility

M Kelly, K Macdougall, O Olabisi, N McGuire - International urogynecology …, 2017 - Springer
Introduction and hypothesis Polypropylene is a material that is commonly used to treat pelvic
floor conditions such as pelvic organ prolapse (POP) and stress urinary incontinence (SUI) …

Urinary incontinence in women

J Goforth, M Langaker - North Carolina medical journal, 2016 - ncmedicaljournal.com
Urinary incontinence, the involuntary loss of urine, can result from a multitude of etiologies
and can have a significant negative impact on a woman9s physical, social, economic, and …

Host response to synthetic mesh in women with mesh complications

AL Nolfi, BN Brown, R Liang, SL Palcsey… - American Journal of …, 2016 - Elsevier
Background Despite good anatomic and functional outcomes, urogynecologic
polypropylene meshes that are used to treat pelvic organ prolapse and stress urinary …

In vitro bacterial adhesion and biofilm formation on fully absorbable poly-4-hydroxybutyrate and nonabsorbable polypropylene pelvic floor implants

KWJ Verhorstert, Z Guler, L de Boer… - … applied materials & …, 2020 - ACS Publications
Knitted polypropylene (PP) implants for the correction of pelvic organ prolapse have been
associated with complications such as vaginal exposure, infection, and pain. Since certain …

Mesh deformation: A mechanism underlying polypropylene prolapse mesh complications in vivo

KM Knight, GE King, SL Palcsey, A Suda, R Liang… - Acta biomaterialia, 2022 - Elsevier
Polypropylene meshes used in pelvic organ prolapse (POP) repair are hampered by
complications. Most POP meshes are highly unstable after tensioning ex vivo, as evidenced …

Characterization of the host inflammatory response following implantation of prolapse mesh in rhesus macaque

BN Brown, D Mani, AL Nolfi, R Liang… - American Journal of …, 2015 - Elsevier
Objective We sought to determine the predominant cell type (macrophage, T lymphocyte, B
lymphocyte, mast cell) within the area of implantation of the prototypical polypropylene …

[HTML][HTML] Assessment of electrospun and ultra-lightweight polypropylene meshes in the sheep model for vaginal surgery

L Hympanova, R Rynkevic, S Roman… - European urology …, 2020 - Elsevier
Background There is an urgent need to develop better materials to provide anatomical
support to the pelvic floor without compromising its function. Objective Our aim was to …

Blended Nanostructured Degradable Mesh with Endometrial Mesenchymal Stem Cells Promotes Tissue Integration and Anti-Inflammatory Response in Vivo for …

S Mukherjee, S Darzi, A Rosamilia, V Kadam… - …, 2018 - ACS Publications
The current urogynecological clinical meshes trigger unfavorable foreign body response
which leads to graft failure in the long term. To overcome the present challenge, we applied …

Electrospun nanofiber meshes with endometrial MSCs modulate foreign body response by increased angiogenesis, matrix synthesis, and anti-inflammatory gene …

S Mukherjee, S Darzi, K Paul, FL Cousins… - Frontiers in …, 2020 - frontiersin.org
Purpose Transvaginal meshes for the treatment of Pelvic Organ Prolapse (POP) have been
associated with severe adverse events and have been banned for clinical use in many …

Design, mechanical and degradation requirements of biodegradable metal mesh for pelvic floor reconstruction

Z Mardina, J Venezuela, C Maher, Z Shi… - Biomaterials …, 2022 - pubs.rsc.org
Pelvic organ prolapse is the herniation of surrounding tissue and organs into the vagina
and/or rectum and is a result of the weakening of pelvic floor muscles, connective tissue, and …