Mechanisms of resistance to aminoglycosides

J Davies, P Courvalin - The American Journal of Medicine, 1977 - Elsevier
Bacterial resistance to aminoglycoside antibiotics occurs by a variety of mechanisms. In
clinical situations the most common mechanism is plasmid-determined modification of the …

Consequences of Ca2+ deficiency on macromolecular synthesis and adenylate energy charge in Yersinia pestis

RJ Zahorchak, WT Charnetzky, RV Little… - Journal of …, 1979 - Am Soc Microbiol
A 37 but not 26 degrees C virulent Yersinia pestis is known to require at least 2.5 mM Ca2+
for growth; this requirement is potentiated by Mg2+. After shift of log-phase cells (doubling …

Mutations determining generalized resistance to aminoglycoside antibiotics in Escherichia coli

SH Thorbjarnardóttir, RÁ Magnúsdóttir… - Molecular and General …, 1978 - Springer
Mutations conferring resistance to low levels of kanamycin in Escherichia coli have been
mapped at 3 locations: the unc locus (min. 83), a locus we have designated, kanA (min. 72) …

Interaction between aminoglycoside uptake and ribosomal resistance mutations

MH Ahmad, A Rechenmacher… - Antimicrobial Agents and …, 1980 - Am Soc Microbiol
Mutants resistant to the 2-deoxystreptamine aminoglycosides hygromycin B and gentamicin
were analyzed biochemically and genetically. In hygromycin B-resistant strains, ribosomal …

In vitro characterization of aminoglycoside adaptive resistance in Pseudomonas aeruginosa

JA Karlowsky, MH Saunders, GA Harding… - Antimicrobial agents …, 1996 - Am Soc Microbiol
Aminoglycoside adaptive resistance was characterized in one reference strain and four
clinical isolates of Pseudomonas aeruginosa. Adaptive resistance was initiated with a 2-h …

Genetic analysis of zwittermicin A resistance in Escherichia coli: effects on membrane potential and RNA polymerase

EV Stabb, J Handelsman - Molecular microbiology, 1998 - Wiley Online Library
Zwittermicin A is a novel aminopolyol antibiotic that represents a new structural class of
antibiotic and has diverse biological activities, including the suppression of plant disease …

Energy transduction in Escherichia coli: new mutation affecting the Fo portion of the ATP synthetase complex

BP Rosen, RN Brey, SM Hasan - Journal of Bacteriology, 1978 - Am Soc Microbiol
A mutation affecting the intrinsic membrane portion (BFo) of the ATP synthetase complex is
described. The phenotype is different from previously reported BFo mutants. This mutation …

The role of the membrane in the bioenergetics of bacterial cells

TA Krulwich, AA Guffanti… - Organization of prokaryotic …, 2018 - taylorfrancis.com
The relative impermeability of the cytoplasmic membrane to protons, and at least some other
cations, may critically relate to the energization of a variety of processes, including ATP …

Gentamicin- and neomycin-resistant mutants of Escherichia coli K-12 cross-resistant to nitrofurans

EE Obaseiki-Ebor, AS Breeze - Journal of Antimicrobial …, 1984 - academic.oup.com
Gentamicin and neomycin-resistant mutants of Escherichia coli K-12 were isolated some of
which were resistant to nitrofurans, chlorate, PI and λ bacterio-phages as well as to all …

Cytoplasmic membrane transport and antimicrobial resistance

LE Bryan - Microbial Resistance to Drugs, 1989 - Springer
Cytoplasmic Membrane Transport and Antimicrobial Resistance Page 1 CHAPTER 2
Cytoplasmic Membrane Transport and Antimicrobial Resistance LE BRYAN A. Summary of …