All metazoans that utilize molecular oxygen (O2) for metabolic purposes have the capacity to
adapt to hypoxia, the condition that arises when O2 demand exceeds supply. This is …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …

MCL1 is essential for the survival of stem and progenitor cells of multiple lineages,, and is
unique among pro-survival BCL2 family members in that it is rapidly turned over through the …

Pancreatic ductal adenocarcinoma (PDA) remains a lethal malignancy despite much
progress concerning its molecular characterization. PDA tumours harbour four signature …

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to JCI Insight About Editors Consulting Editors For authors Publication ethics Alerts Advertising …

The heptahelical G protein–coupled receptors (GPCRs) belong to the largest family of cell
surface signaling receptors encoded in the human genome. GPCRs signal to diverse …

Deubiquitylating enzymes (DUBs), act downstream of ubiquitylation. As such, these post-
post-translational modifiers function as the final arbitrators of a protein substrate's …

Ubiquitylation is a fundamental mechanism of signal transduction that regulates immune
responses and many other biological processes. Similar to phosphorylation, ubiquitylation is …

Triple-negative breast cancer (TNBC) is a breast cancer subtype that lacks targeted
treatment options. The activation of the Notch developmental signaling pathway, which is a …

AMPK (AMP-activated protein kinase)-related kinases regulate cell polarity as well as
proliferation and are activated by the LKB1-tumour suppressor kinase. In the present study …