Nerve–cancer cell cross-talk: a novel promoter of tumor progression
Recent studies have revealed the essential role played by nerves in tumor progression.
Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate …
Nerves have been shown to infiltrate the tumor microenvironment and actively stimulate …
[HTML][HTML] Sorting through the extensive and confusing roles of sortilin in metabolic disease
Sortilin is a post-Golgi trafficking receptor homologous to the yeast vacuolar protein sorting
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …
receptor 10 (VPS10). The VPS10 motif on sortilin is a 10-bladed β-propeller structure …
An intronic ncRNA-dependent regulation of SORL1 expression affecting Aβ formation is upregulated in post-mortem Alzheimer's disease brain samples
E Ciarlo, S Massone, I Penna… - Disease models & …, 2013 - journals.biologists.com
Recent studies indicated that sortilin-related receptor 1 (SORL1) is a risk gene for late-onset
Alzheimer's disease (AD), although its role in the aetiology and/or progression of this …
Alzheimer's disease (AD), although its role in the aetiology and/or progression of this …
Targeting neurotrophin signaling in cancer: The renaissance
Nerve outgrowth in the tumor microenvironment (tumor neurogenesis) has recently been
shown to be essential for cancer progression and the concept of nerve dependence is …
shown to be essential for cancer progression and the concept of nerve dependence is …
Deciphering proneurotrophin actions
BL Hempstead - Neurotrophic factors, 2014 - Springer
Like most growth factors, neurotrophins are initially synthesized as precursors that are
cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins …
cleaved to release C-terminal mature forms. The well-characterized mature neurotrophins …
NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling
RA Bradshaw, J Pundavela, J Biarc, RJ Chalkley… - Advances in biological …, 2015 - Elsevier
Nerve growth factor (NGF) and its precursor (proNGF) are primarily considered as regulators
of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and …
of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and …
[HTML][HTML] ProNGF, but not NGF, switches from neurotrophic to apoptotic activity in response to reductions in TrkA receptor levels
MS Ioannou, M Fahnestock - International journal of molecular sciences, 2017 - mdpi.com
Nerve growth factor (NGF) promotes the survival and differentiation of neurons. NGF is
initially synthesized as a precursor, proNGF, which is the predominant form in the central …
initially synthesized as a precursor, proNGF, which is the predominant form in the central …
Role of p75 neurotrophin receptor in stem cell biology: more than just a marker
E Tomellini, C Lagadec, R Polakowska… - Cellular and molecular …, 2014 - Springer
Abstract p75 NTR, the common receptor for both neurotrophins and proneurotrophins, has
been widely studied because of its role in many tissues, including the nervous system. More …
been widely studied because of its role in many tissues, including the nervous system. More …
Neurotrophins and their receptors in breast cancer
H Hondermarck - Cytokine & growth factor reviews, 2012 - Elsevier
Growth factors of the neurotrophin family and their receptors have been mainly studied in the
nervous system, but they are also expressed in carcinomas, and in breast cancer they …
nervous system, but they are also expressed in carcinomas, and in breast cancer they …
EphA2: A promising therapeutic target in breast cancer
P Zhao, D Jiang, Y Huang, C Chen - Journal of Genetics and Genomics, 2021 - Elsevier
Ephrin type-A receptor 2 (EphA2), a receptor tyrosine kinase, is overexpressed in human
breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates …
breast cancers often linked to poor patient prognosis. Accumulating evidence demonstrates …