What's in a Gene? The Outstanding Diversity of MAPT

D Ruiz-Gabarre, A Carnero-Espejo, J Ávila… - Cells, 2022 - mdpi.com
Tau protein is a microtubule-associated protein encoded by the MAPT gene that carries out
a myriad of physiological functions and has been linked to certain pathologies collectively …

Multivalent Tau/PSD-95 interactions arrest in vitro condensates and clusters mimicking the postsynaptic density

Z Shen, D Sun, A Savastano, SJ Varga… - Nature …, 2023 - nature.com
Alzheimer's disease begins with mild memory loss and slowly destroys memory and
thinking. Cognitive impairment in Alzheimer's disease has been associated with the …

Tau target identification reveals NSF‐dependent effects on AMPA receptor trafficking and memory formation

E Prikas, E Paric, PR Asih, K Stefanoska… - The EMBO …, 2022 - embopress.org
Microtubule‐associated protein tau is a central factor in Alzheimer's disease and other
tauopathies. However, the physiological functions of tau are unclear. Here, we used …

Cyclosporine A (CsA) prevents synaptic impairment caused by truncated tau by caspase-3

C Tapia-Monsalves, MA Olesen… - Molecular and Cellular …, 2023 - Elsevier
Abstract During Alzheimer's (AD), tau protein suffers from abnormal post-translational
modifications, including cleaving by caspase-3. These tau forms affect synaptic plasticity …

Lipid peroxidation induced ApoE receptor-ligand disruption as a unifying hypothesis underlying sporadic Alzheimer's disease in humans

CE Ramsden, GS Keyes, E Calzada… - Journal of …, 2022 - content.iospress.com
Background: Sporadic Alzheimer's disease (sAD) lacks a unifying hypothesis that can
account for the lipid peroxidation observed early in the disease, enrichment of ApoE in the …

Disease progression and genetic risk factors in the primary tauopathies

WJ Scotton - 2023 - search.proquest.com
The primary tauopathies are a group of progressive neurodegenerative diseases within the
frontotemporal lobar degeneration spectrum (FTLD) characterised by the accumulation of …

Formation, regulation and dynamics of phase separated postsynaptic density condensates with Tau and Fyn

Z Shen - 2024 - ediss.uni-goettingen.de
Formation, regulation and dynamics of phase- separated postsynaptic density condensates
with Tau and Fyn Zheng Shen Page 1 i Formation, regulation and dynamics of phaseseparated …

[HTML][HTML] The Role of TRKB Receptor Complex Proteins and the Lipid Environment In the Mechanism of Antidepressant Drug Action

SM Fred - 2022 - helda.helsinki.fi
Brain plasticity, in its simplest definition, is the ability of brain to change itself. This
phenomenon, which is important for the development and wiring of neuronal networks, is …

The Role of Tau in Depression Via the Microtubule Dynamic by Several Regulators: A Review

H Wang, C Yang, Z Zhu - Available at SSRN 4129732 - papers.ssrn.com
Objectives: There is growing evidence that the tau protein plays an essential role in
Alzheimer's disease. However, an increasing number of researchers have recently focus on …