Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …

PURPOSE Treatment planning for children with neuroblastoma requires accurate
assessment of prognosis. The most recent Children's Oncology Group (COG) risk …

Abstract Learning Objectives After completing this course, the reader will be able to:
Appreciate the heterogeneity of neuroblastoma and identify clinical and biological …

PURPOSE: Stage IV-S neuroblastoma is a metastatic disease associated with spontaneous
regression and good survival, but 10% to 20% of infants die from early complications. The …

Abstract N-myc (MYCN), a member of the Myc family of basic-helix–loop–helix–zipper
(bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such …

Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …

PURPOSE: To determine prospectively whether surgery alone is sufficient therapy for Evans
stages I and II neuroblastoma and to define biologic and clinical features having prognostic …

PURPOSE Although a high rate of spontaneous regression is observed in infants with stage
D (S) neuroblastoma (NB), survival is not uniform. To determine the prognostic relevance of …

Although most studies have reported that high serum lactate dehydrogenase (LDH) levels
are associated with poor prognosis in several malignancies, the consistency and magnitude …

Chemotherapy protocols for childhood cancers are still problematic due to the high toxicity
associated with chemotherapeutic agents and incorrect dosing regimens extrapolated from …