Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …

Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Psychological stress is a crucial factor in the development of many skin diseases, and the
stigma caused by skin disorders may further increase the psychological burden, forming a …

Psoriasis vulgaris and other chronic inflammatory diseases improve markedly with
therapeutic blockade of interleukin-23 (IL-23) signaling, but the genetic mechanisms …

The facilitative GLUT1 and GLUT3 hexose transporters are expressed abundantly in
macrophages, but whether they have distinct functions remains unclear. We confirmed that …

Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion,
limiting adaptive immunity. In contrast, aberrant, sustained T cell responses can persist over …

The stratum corneum (SC) and cell membrane are two major barriers that hinder the
therapeutic outcomes of transdermal drug delivery for the treatment of skin diseases. While …

Summary CD69+ CD103+ tissue-resident memory T (T RM) cells are important drivers of
inflammation. To decipher their role in inflammatory arthritis, we apply single-cell, high …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …