Tissues are dynamically shaped by bidirectional communication between resident cells and
the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Metastasis is the primary cause of death in breast cancer patients. Early detection of high-
risk breast cancer, including micrometastasis, is critical in tailoring appropriate and effective …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very
restricted pattern of expression but an enormously diverse range of functions. Here, we …

Normal tissue homeostasis and architecture restrain tumor growth. Thus, for a tumor to
develop and spread, malignant cells must overcome growth-repressive inputs from …

The roles of the extracellular matrix molecule tenascin-C (TNC) in health and disease have
been extensively reviewed since its discovery over 40 years ago. Here, we will describe …

The extracellular matrix protein tenascin C (TNC) is a large glycoprotein expressed in
connective tissues and stem cell niches. TNC over-expression is repeatedly observed in …

Tenascins are extracellular matrix proteins with distinct spatial and temporal expression
during development, tissue homeostasis and disease. Based on their expression patterns …