Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis

CR Ferraz, A Arrahman, C Xie, NR Casewell… - Frontiers in ecology …, 2019 - frontiersin.org
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …

[HTML][HTML] A current perspective on snake venom composition and constituent protein families

T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …

Snake venom peptides: Tools of biodiscovery

A Munawar, SA Ali, A Akrem, C Betzel - Toxins, 2018 - mdpi.com
Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …

Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine

S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …

Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom …

LF Sousa, CN Zdenek, JS Dobson, B Op den Brouw… - Toxins, 2018 - mdpi.com
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important
group responsible for the greatest number of snakebite envenomations and deaths in South …

The pharmacology of voltage-gated sodium channel activators

JR Deuis, A Mueller, MR Israel, I Vetter - Neuropharmacology, 2017 - Elsevier
Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)

V Cipriani, J Debono, J Goldenberg… - … and Physiology Part C …, 2017 - Elsevier
Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution
across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly …

[HTML][HTML] Last decade update for three-finger toxins: Newly emerging structures and biological activities

YN Utkin - World journal of biological chemistry, 2019 - ncbi.nlm.nih.gov
Three-finger toxins (TFTs) comprise one of largest families of snake venom toxins. While
they are principal to and the most toxic components of the venoms of the Elapidae snake …

Sodium channels and venom peptide pharmacology

MR Israel, B Tay, JR Deuis, I Vetter - Advances in pharmacology, 2017 - Elsevier
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have
evolved a myriad of components in their venoms that target the opening and/or closing of …

Venoms of rear-fanged snakes: new proteins and novel activities

CM Modahl, SP Mackessy - Frontiers in Ecology and Evolution, 2019 - frontiersin.org
Snake venom research has focused on front-fanged venomous snakes because of the high
incidence of human morbidity and mortality from envenomations and larger venom yields of …