Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis
Animal venoms have evolved over millions of years for prey capture and defense from
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
predators and rivals. Snake venoms, in particular, have evolved a wide diversity of peptides …
[HTML][HTML] A current perspective on snake venom composition and constituent protein families
T Tasoulis, GK Isbister - Archives of toxicology, 2023 - Springer
Snake venoms are heterogeneous mixtures of proteins and peptides used for prey
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …
subjugation. With modern proteomics there has been a rapid expansion in our knowledge of …
Snake venom peptides: Tools of biodiscovery
Nature endowed snakes with a lethal secretion known as venom, which has been fine-tuned
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …
over millions of years of evolution. Snakes utilize venom to subdue their prey and to survive …
Snake three-finger α-neurotoxins and nicotinic acetylcholine receptors: Molecules, mechanisms and medicine
S Nirthanan - Biochemical pharmacology, 2020 - Elsevier
Snake venom three-finger α-neurotoxins (α-3FNTx) act on postsynaptic nicotinic
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …
acetylcholine receptors (nAChRs) at the neuromuscular junction (NMJ) to produce skeletal …
Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom …
Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important
group responsible for the greatest number of snakebite envenomations and deaths in South …
group responsible for the greatest number of snakebite envenomations and deaths in South …
The pharmacology of voltage-gated sodium channel activators
Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …
evolved numerous times due to the importance of this class of ion channels in the normal …
Correlation between ontogenetic dietary shifts and venom variation in Australian brown snakes (Pseudonaja)
V Cipriani, J Debono, J Goldenberg… - … and Physiology Part C …, 2017 - Elsevier
Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution
across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly …
across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly …
[HTML][HTML] Last decade update for three-finger toxins: Newly emerging structures and biological activities
YN Utkin - World journal of biological chemistry, 2019 - ncbi.nlm.nih.gov
Three-finger toxins (TFTs) comprise one of largest families of snake venom toxins. While
they are principal to and the most toxic components of the venoms of the Elapidae snake …
they are principal to and the most toxic components of the venoms of the Elapidae snake …
Sodium channels and venom peptide pharmacology
Venomous animals including cone snails, spiders, scorpions, anemones, and snakes have
evolved a myriad of components in their venoms that target the opening and/or closing of …
evolved a myriad of components in their venoms that target the opening and/or closing of …
Venoms of rear-fanged snakes: new proteins and novel activities
CM Modahl, SP Mackessy - Frontiers in Ecology and Evolution, 2019 - frontiersin.org
Snake venom research has focused on front-fanged venomous snakes because of the high
incidence of human morbidity and mortality from envenomations and larger venom yields of …
incidence of human morbidity and mortality from envenomations and larger venom yields of …