Purinergic signalling plays major roles in the physiology and pathophysiology of digestive
organs. Adenosine 5′-triphosphate (ATP), together with nitric oxide and vasoactive …

When the body is challenged by pathogens during infections, the first‑line defense for the
host is provided by the innate immune system which encom‑passes various cell types such …

Adenosine is an endogenous purine nucleoside that acts in all living systems as a
homeostatic network regulator through many pathways, which are adenosine receptor (AR) …

Interest in adenosine deaminase (ADA) in the context of medicine has mainly focused on its
enzymatic activity. This is justified by the importance of the reaction catalyzed by ADA not …

Adenosine deaminase (ADA) is an enzyme of purine metabolism that irreversibly converts
adenosine to inosine or 2′ deoxyadenosine to 2′ deoxyinosine. ADA is active both inside …

Rheumatoid arthritis (RA) is a classic inflammatory autoimmune disease. Local joint
destruction and extra-articular manifestations of RA deeply compromise the life quality of the …

Purinergic signaling system plays a pivotal role in the trigeminal ganglion (TG) which is a
primary sensory tissue in vertebrate nervous systems involving orofacial nociception and …

The effect of quercetin was assessed in rats induced with complete Freund adjuvant (CFA).
Arthritis scores, paw oedema, latency, activities of myeloperoxidase (MPO), ectonucleoside …

The etiological agent of coronavirus disease (COVID-19) is the new member of the
Coronaviridae family, a severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV …

Humans and other higher primates are unique among mammals in using complement
receptor 1 (CR1, CD35) on red blood cells (RBC) to ligate complement-tagged inflammatory …