The proteostasis network and its decline in ageing
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …
Pathways of cellular proteostasis in aging and disease
CL Klaips, GG Jayaraj, FU Hartl - Journal of Cell Biology, 2018 - rupress.org
Ensuring cellular protein homeostasis, or proteostasis, requires precise control of protein
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
synthesis, folding, conformational maintenance, and degradation. A complex and adaptive …
[HTML][HTML] Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme
G Chen, L Tong, S Huang, S Huang, F Zhu… - Nature …, 2022 - nature.com
Nature programs the structural folding of an enzyme that allows its on-demand
biofunctionality; however, it is still a long-standing challenge to manually modulate an …
biofunctionality; however, it is still a long-standing challenge to manually modulate an …
In vivo aspects of protein folding and quality control
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
[HTML][HTML] HSP70 multi-functionality in cancer
Z Albakova, GA Armeev, LM Kanevskiy, EI Kovalenko… - Cells, 2020 - mdpi.com
The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …
Conotoxins: chemistry and biology
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …
and defense, providing the basis for survival and rapid diversification of the now estimated …
[HTML][HTML] Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion
Cells routinely compartmentalize enzymes for enhanced efficiency of their metabolic
pathways. Here we report a general approach to construct DNA nanocaged enzymes for …
pathways. Here we report a general approach to construct DNA nanocaged enzymes for …
Molecular chaperones in protein folding and proteostasis
Most proteins must fold into defined three-dimensional structures to gain functional activity.
But in the cellular environment, newly synthesized proteins are at great risk of aberrant …
But in the cellular environment, newly synthesized proteins are at great risk of aberrant …
Molecular chaperone functions in protein folding and proteostasis
The biological functions of proteins are governed by their three-dimensional fold. Protein
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
folding, maintenance of proteome integrity, and protein homeostasis (proteostasis) critically …
[HTML][HTML] Protein quality control and elimination of protein waste: The role of the ubiquitin–proteasome system
I Amm, T Sommer, DH Wolf - … et Biophysica Acta (BBA)-Molecular Cell …, 2014 - Elsevier
Mistakes are part of our world and constantly occurring. Due to transcriptional and
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …
translational failures, genomic mutations or diverse stress conditions like oxidation or heat …