The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors

KH Darwin, SA Stanley - Open Biology, 2022 - royalsocietypublishing.org
There are many reactive intermediates found in metabolic pathways. Could these potentially
toxic molecules be exploited for an organism's benefit? We propose that during certain …

[HTML][HTML] Prospective approach of Swietenia macrophylla as a neuroprotective agent for Alzheimer's Disease: Emphasis on ameliorative mechanism

I Jazuli, GB Hing, L Selvaratnam, LL Han, D Alex… - Journal of Functional …, 2023 - Elsevier
Alzheimer's disease (AD) poses a significant challenge to healthcare systems and
economics worldwide in the 21st century. It is characterised by progressive memory …

An On‐Demand Collaborative Innate–Adaptive Immune Response to Infection Treatment

L Chen, Z Shao, Z Zhang, W Teng, H Mou… - Advanced …, 2024 - Wiley Online Library
Deep tissue infection is a common clinical issue and therapeutic difficulty caused by the
disruption of the host antibacterial immune function, resulting in treatment failure and …

Fast and sensitive UHPLC-QqQ-MS/MS method for simultaneous determination of typical α, β-unsaturated aldehydes and malondialdehyde in various vegetable oils …

L Ma, Y Cui, F Wang, H Liu, W Cheng, L Peng… - Food Chemistry, 2023 - Elsevier
This study aimed to develop and evaluate a method for simultaneously analyzing
malondialdehyde (MDA) and two typical toxic α, β-unsaturated aldehydes, 4-hydroxy-2 …

Disruption of aldehyde dehydrogenase 2 protects against bacterial infection

SB Berry, S Espich, NTT Thuong, X Chang, R Dorajoo… - bioRxiv, 2023 - biorxiv.org
Abstract The ALDH2* 2 (rs671) allele is one of the most common genetic mutations in
humans, yet the positive evolutionary selective pressure to maintain this mutation is …

[HTML][HTML] Simultaneous determination of typical toxic aldehydes formed during food frying and digestion using isotope dilution UHPLC-QqQ-MS/MS

F Wang, Y Cui, D Liu, C Brennan, S Benjakul… - Grain & Oil Science and …, 2024 - Elsevier
An isotope dilution ultra-performance liquid chromatography–triple quadrupole mass
spectrometry method was developed to simultaneously detect two typical kinds of α, β …

Experimental Evolution Reveals a Novel Ene Reductase That Detoxifies α, β-Unsaturated Aldehydes in Listeria monocytogenes

L Sun, A Van Loey, C Buvé, CW Michiels - Microbiology Spectrum, 2023 - Am Soc Microbiol
The plant essential oil component trans-cinnamaldehyde (t-CIN) exhibits antibacterial
activity against a broad range of foodborne pathogenic bacteria, including L …

[HTML][HTML] Overview of the Lipid Peroxidation Measurements in Patients by the Enzyme-Linked Immunosorbent Assay Specific for the 4-Hydroxynonenal-Protein Adducts …

N Žarković, A Gęgotek, W Łuczaj… - Frontiers in Bioscience …, 2024 - imrpress.com
Oxidative stress often affects the structure and metabolism of lipids, which in the case of
polyunsaturated free fatty acids (PUFAs) leads to a self-catalysed chain reaction of lipid …

[PDF][PDF] ISOLATION AND CHARACTERIZATION OF MUTANTS WITH ALTERED SENSITIVITY TO THE NATURAL ANTIMICROBIAL TRANS-CINNAMALDEHYDE IN …

L Sun - 2022 - lirias.kuleuven.be
Listeria monocytogenes is a Gram-positive, rod-shaped, non-sporulating, and facultative
aerobic member of the bacterial Firmicutes phylum, that causes relatively rare but severe …