Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications
YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …
[HTML][HTML] Controlling timing and location in vaccines
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …
immune response induced by immunization arises following appropriate activation and …
Controlling the SARS-CoV-2 spike glycoprotein conformation
R Henderson, RJ Edwards, K Mansouri… - Nature structural & …, 2020 - nature.com
The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary
immunogenic target for virus neutralization and the current focus of many vaccine design …
immunogenic target for virus neutralization and the current focus of many vaccine design …
Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
PJM Brouwer, M Brinkkemper, P Maisonnasse… - Cell, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle
The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …
Cross-reactive antibodies after SARS-CoV-2 infection and vaccination
M Grobben, K van der Straten, PJM Brouwer… - Elife, 2021 - elifesciences.org
Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …
Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site
TG Caniels, M Medina-Ramìrez, S Zhang… - Science …, 2024 - science.org
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …
Antigen identification and high-throughput interaction mapping by reprogramming viral entry
CS Dobson, AN Reich, S Gaglione, BE Smith, EJ Kim… - Nature …, 2022 - nature.com
Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …
Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques
SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting
high titres of neutralising antibodies against the viral spike (S). However, the merits of …
high titres of neutralising antibodies against the viral spike (S). However, the merits of …
Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate
K Sliepen, L Radić, J Capella-Pujol… - Nature …, 2022 - nature.com
Hepatitis C virus (HCV) infection affects approximately 58 million people and causes~
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …