Viral nanoparticles for drug delivery, imaging, immunotherapy, and theranostic applications

YH Chung, H Cai, NF Steinmetz - Advanced Drug Delivery Reviews, 2020 - Elsevier
Viral nanoparticles (VNPs) encompass a diverse array of naturally occurring nanomaterials
derived from plant viruses, bacteriophages, and mammalian viruses. The application and …

[HTML][HTML] Controlling timing and location in vaccines

DJ Irvine, A Aung, M Silva - Advanced Drug Delivery Reviews, 2020 - Elsevier
Vaccines are one of the most powerful technologies supporting public health. The adaptive
immune response induced by immunization arises following appropriate activation and …

Controlling the SARS-CoV-2 spike glycoprotein conformation

R Henderson, RJ Edwards, K Mansouri… - Nature structural & …, 2020 - nature.com
The coronavirus (CoV) spike (S) protein, involved in viral–host cell fusion, is the primary
immunogenic target for virus neutralization and the current focus of many vaccine design …

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

PJM Brouwer, M Brinkkemper, P Maisonnasse… - Cell, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is
continuing to disrupt personal lives, global healthcare systems, and economies. Hence …

Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

PJM Brouwer, A Antanasijevic, Z Berndsen… - Nature …, 2019 - nature.com
The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the
induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 …

Cross-reactive antibodies after SARS-CoV-2 infection and vaccination

M Grobben, K van der Straten, PJM Brouwer… - Elife, 2021 - elifesciences.org
Current SARS-CoV-2 vaccines are losing efficacy against emerging variants and may not
protect against future novel coronavirus outbreaks, emphasizing the need for more broadly …

Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site

TG Caniels, M Medina-Ramìrez, S Zhang… - Science …, 2024 - science.org
Eliciting potent and broadly neutralizing antibodies (bnAbs) is a major goal in HIV-1 vaccine
development. Here, we describe how germline-targeting immunogen BG505 SOSIP …

Antigen identification and high-throughput interaction mapping by reprogramming viral entry

CS Dobson, AN Reich, S Gaglione, BE Smith, EJ Kim… - Nature …, 2022 - nature.com
Deciphering immune recognition is critical for understanding a broad range of diseases and
for the development of effective vaccines and immunotherapies. Efforts to do so are limited …

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

HX Tan, JA Juno, WS Lee, I Barber-Axthelm… - Nature …, 2021 - nature.com
SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting
high titres of neutralising antibodies against the viral spike (S). However, the merits of …

Induction of cross-neutralizing antibodies by a permuted hepatitis C virus glycoprotein nanoparticle vaccine candidate

K Sliepen, L Radić, J Capella-Pujol… - Nature …, 2022 - nature.com
Hepatitis C virus (HCV) infection affects approximately 58 million people and causes~
300,000 deaths yearly. The only target for HCV neutralizing antibodies is the highly …