Timely and faithful duplication of the entire genome depends on completion of replication.
Replication forks frequently encounter obstacles that may cause genotoxic fork stalling …

Proteins covalently attached to DNA, also known as DNA–protein crosslinks (DPCs), are
common and bulky DNA lesions that interfere with DNA replication, repair, transcription and …

Genome-wide association studies (GWASs) have discovered numerous risk genes for
Alzheimer's disease (AD), but how these genes confer AD risk is challenging to decipher. To …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

Naturally occurring or drug-induced DNA-protein crosslinks (DPCs) interfere with key DNA
transactions if not repaired in a timely manner. The unique family of DPC-specific proteases …

The Ddi1/DDI2 proteins are ubiquitin shuttling factors, implicated in a variety of cellular
functions. In addition to ubiquitin-binding and ubiquitin-like domains, they contain a …

Proteins that act on DNA, or are in close proximity to it, can become inadvertently
crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs) …

Innovative methods to retrieve proteins associated with actively replicating DNA have
provided a glimpse into the molecular dynamics of replication fork stalling. We report that a …

The characteristics and fate of cancer cells partly depend on their environmental stiffness, ie,
the local mechanical cues they face. HepaRG progenitors are liver carcinoma cells …

Proteasome inhibition is used therapeutically to induce proteotoxic stress and trigger
apoptosis in cancer cells that are highly dependent on the proteasome. As a mechanism of …