Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA
double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and …

Rare pleiotropic genetic disorders, Ataxia-telangiectasia (AT), Bloom syndrome (BS) and
Nijmegen breakage syndrome (NBS) are characterised by immunodeficiency, extreme …

A variety of human neurologic diseases are caused by inherited defects in DNA repair. In
many cases, these syndromes almost exclusively impact the nervous system, underscoring …

Objectives: High dose-rate ionizing radiation (IR) causes severe DSB damage, as well as
reactive oxygen species (ROS) accumulation and oxidative stress. However, it is unknown …

Ataxia Telangiectasia Mutated protein kinase (ATM) has recently come to the fore as a
regulatory protein fulfilling many roles in the fine balancing act of metabolic homeostasis …

Ataxia-telangiectasia (AT) and MRE11-defective Ataxia-telangiectasia-like disorder (ATLD)
patients show progressive cerebellar ataxia. ATM, mutated in AT, can be activated in …

Nijmegen breakage syndrome (NBS), a condition similar to Ataxia-Telangiectasia (AT), is a
radiation-hypersensitive genetic disorder showing chromosomal instability, radio-resistant …

Polyglutamine diseases comprise a cluster of genetic disorders involving
neurodegeneration and movement disabilities. In polyglutamine diseases, the target …

Introduction. Ataxia‐telangiectasia‐mutated (ATM) kinase is a master regulator of the DNA
damage response and is directly activated by reactive oxygen species (ROSs) in addition to …

Various biological responses occur when cells are exposed to endogenous and exogenous
stress such as DNA damage, replication stress, and oxidative stress. To maintain genome …