Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …
Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture
Y Hachemi, AE Rapp, AK Picke… - Journal of …, 2018 - jme.bioscientifica.com
Glucocorticoid hormones (GCs) have profound effects on bone metabolism. Via their nuclear
hormone receptor–the GR–they act locally within bone cells and modulate their proliferation …
hormone receptor–the GR–they act locally within bone cells and modulate their proliferation …
In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome
A Pintatum, W Maneerat, E Logie, E Tuenter… - Biomolecules, 2020 - mdpi.com
The genus Curcuma is part of the Zingiberaceae family, and many Curcuma species have
been used as traditional medicine and cosmetics in Thailand. To find new cosmeceutical …
been used as traditional medicine and cosmetics in Thailand. To find new cosmeceutical …
[HTML][HTML] The long winding road to the safer glucocorticoid receptor (GR) targeting therapies
Glucocorticoids (Gcs) are widely used to treat inflammatory diseases and hematological
malignancies, and despite the introduction of novel anti-inflammatory and anti-cancer …
malignancies, and despite the introduction of novel anti-inflammatory and anti-cancer …
[HTML][HTML] Glucocorticoid receptor
The glucocorticoid receptor (GR) is an evolutionally conserved nuclear receptor superfamily
protein that mediates the diverse actions of glucocorticoids as a ligand-dependent …
protein that mediates the diverse actions of glucocorticoids as a ligand-dependent …
Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat …
K Declerck, CP Novo, L Grielens, G Van Camp… - … Medicine and Therapies, 2021 - Springer
Abstract Background Herbal remedies of Echinacea purpurea tinctures are widely used
today to reduce common cold respiratory tract infections. Methods Transcriptome …
today to reduce common cold respiratory tract infections. Methods Transcriptome …
Antioxidant and anti-aging enzyme activities of bioactive compounds isolated from selected Zingiberaceae plants
R Rungruang, W Ratanathavorn… - Agriculture and …, 2021 - li01.tci-thaijo.org
Bioactive compounds and antioxidant and enzyme inhibition activity levels were evaluated
for three plants in the Zingiberaceae family in Thailand. Quantification of the phenolic and …
for three plants in the Zingiberaceae family in Thailand. Quantification of the phenolic and …
Variation in glucocorticoid sensitivity and the relation with obesity
R Lengton, AM Iyer, ES van der Valk… - Obesity …, 2022 - Wiley Online Library
Increasing evidence points to a relation between increased glucocorticoid (GC) exposure
and weight gain. In support, long‐term cortisol measurements using hair analysis revealed …
and weight gain. In support, long‐term cortisol measurements using hair analysis revealed …
5α‐Tetrahydrocorticosterone: A topical anti‐inflammatory glucocorticoid with an improved therapeutic index in a murine model of dermatitis
DEW Livingstone, K Sooy, C Sykes… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Glucocorticoids are powerful anti‐inflammatory drugs, but
are associated with many side‐effects. Topical application in atopic dermatitis leads to skin …
are associated with many side‐effects. Topical application in atopic dermatitis leads to skin …
Covalent ligands of nuclear receptors
Nuclear receptors (NRs) are ligand-induced transcriptional factors implicated in several
physiological pathways. Naïve ligands bind to their cognate receptors and modulate gene …
physiological pathways. Naïve ligands bind to their cognate receptors and modulate gene …