Treating the Side Effects of Exogenous Glucocorticoids; Can We Separate the Good From the Bad?

R Pofi, G Caratti, DW Ray, JW Tomlinson - Endocrine Reviews, 2023 - academic.oup.com
It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Molecular mechanisms of glucocorticoids on skeleton and bone regeneration after fracture

Y Hachemi, AE Rapp, AK Picke… - Journal of …, 2018 - jme.bioscientifica.com
Glucocorticoid hormones (GCs) have profound effects on bone metabolism. Via their nuclear
hormone receptor–the GR–they act locally within bone cells and modulate their proliferation …

In Vitro Anti-Inflammatory, Anti-Oxidant, and Cytotoxic Activities of Four Curcuma Species and the Isolation of Compounds from Curcuma aromatica Rhizome

A Pintatum, W Maneerat, E Logie, E Tuenter… - Biomolecules, 2020 - mdpi.com
The genus Curcuma is part of the Zingiberaceae family, and many Curcuma species have
been used as traditional medicine and cosmetics in Thailand. To find new cosmeceutical …

[HTML][HTML] The long winding road to the safer glucocorticoid receptor (GR) targeting therapies

EA Lesovaya, D Chudakova, G Baida, EM Zhidkova… - Oncotarget, 2022 - ncbi.nlm.nih.gov
Glucocorticoids (Gcs) are widely used to treat inflammatory diseases and hematological
malignancies, and despite the introduction of novel anti-inflammatory and anti-cancer …

[HTML][HTML] Glucocorticoid receptor

NC Nicolaides, G Chrousos, T Kino - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
The glucocorticoid receptor (GR) is an evolutionally conserved nuclear receptor superfamily
protein that mediates the diverse actions of glucocorticoids as a ligand-dependent …

Echinacea purpurea (L.) Moench treatment of monocytes promotes tonic interferon signaling, increased innate immunity gene expression and DNA repeat …

K Declerck, CP Novo, L Grielens, G Van Camp… - … Medicine and Therapies, 2021 - Springer
Abstract Background Herbal remedies of Echinacea purpurea tinctures are widely used
today to reduce common cold respiratory tract infections. Methods Transcriptome …

Antioxidant and anti-aging enzyme activities of bioactive compounds isolated from selected Zingiberaceae plants

R Rungruang, W Ratanathavorn… - Agriculture and …, 2021 - li01.tci-thaijo.org
Bioactive compounds and antioxidant and enzyme inhibition activity levels were evaluated
for three plants in the Zingiberaceae family in Thailand. Quantification of the phenolic and …

Variation in glucocorticoid sensitivity and the relation with obesity

R Lengton, AM Iyer, ES van der Valk… - Obesity …, 2022 - Wiley Online Library
Increasing evidence points to a relation between increased glucocorticoid (GC) exposure
and weight gain. In support, long‐term cortisol measurements using hair analysis revealed …

5α‐Tetrahydrocorticosterone: A topical anti‐inflammatory glucocorticoid with an improved therapeutic index in a murine model of dermatitis

DEW Livingstone, K Sooy, C Sykes… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Glucocorticoids are powerful anti‐inflammatory drugs, but
are associated with many side‐effects. Topical application in atopic dermatitis leads to skin …

Covalent ligands of nuclear receptors

S Rajan, HS Yoon - European Journal of Medicinal Chemistry, 2023 - Elsevier
Nuclear receptors (NRs) are ligand-induced transcriptional factors implicated in several
physiological pathways. Naïve ligands bind to their cognate receptors and modulate gene …