Bone remodeling is essential for adult bone homeostasis. It comprises two phases: bone
formation and resorption. The balance between the two phases is crucial for sustaining bone …

Bone is a complex tissue that provides mechanical support for muscles and joints, protection
for vital organs, a mineral reservoir that is essential for calcium homeostasis, and the …

A causal role was recently attributed to inflammation in many malignant diseases, including
breast cancer. The different inflammatory mediators that are involved in this disease include …

The epidermal growth factor receptor (EGFR) regulates key processes of cell biology,
including proliferation, survival, and differentiation during development, tissue homeostasis …

Bone metastasis is mediated by complex interactions between tumor cells and resident
stromal cells in the bone microenvironment. The functions of metalloproteinases in organ …

Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths
worldwide. The majority of patients are diagnosed in advanced disease stage. Bone …

Background Multiple myeloma (MM) is a clonal plasma cell malignancy associated with
osteolytic bone disease. Recently, the role of MM-derived exosomes in the …

Metastatic spread of cancer to distant vital organs, including lung and bone, is the
overwhelming cause of breast cancer mortality and morbidity. Effective treatment of systemic …

Maintaining bone architecture requires continuous generation of osteoblasts from
osteoprogenitor pools. Our previous study of mice with epidermal growth factor receptor …

The epidermal growth factor receptor (EGFR) is a member of the ErbB family of receptor
tyrosine kinases. This family includes EGFR/ErbB1/HER1, ErbB2/HER2/Neu ErbB3/HER3 …