The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Cerebral “microvascular” disease occurs in lacunar stroke, leukoaraiosis, vascular dementia
and Alzheimer's disease. It may arise from or contribute to insidious damage to the blood …

Vascular cognitive impairment (VCI) is the diagnostic term used to describe a
heterogeneous group of sporadic and hereditary diseases of the large and small blood …

Matrix metalloproteinases (MMPs) are important in injury and recovery in ischemic injury.
They are proteolytic enzymes that degrade all components of the extracellular matrix (ECM) …

Objective Lacunar stroke is common (25% of ischemic strokes) and mostly because of an
intrinsic cerebral microvascular disease of unknown cause. Although considered primarily to …

Prevalence of dementia continues to increase because of the aging population and limited
treatment options. Cerebral small vessel disease and Alzheimer disease are the two most …

Neurovascular pathology concurs with protein accumulation, as the brain vasculature is
important for waste clearance. Interstitial solutes, such as amyloid-β, were previously …

Cerebral small vessel disease (SVD) is a major cause of stroke and dementia.
Pathologically, three lesions are seen: small vessel arteriopathy, lacunar infarction, and …

The blood–brain barrier is a dynamic and highly organized structure that strictly regulates
the molecules allowed to cross the brain vasculature into the central nervous system. The …