Most viral peptides displayed by class I MHC on infected cells are immunogenic
NP Croft, SA Smith, J Pickering… - Proceedings of the …, 2019 - National Acad Sciences
CD8+ T cells are essential effectors in antiviral immunity, recognizing short virus-derived
peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the …
peptides presented by MHC class I (pMHCI) on the surface of infected cells. However, the …
Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system
T cell epitope candidates are commonly identified using computational prediction tools in
order to enable applications such as vaccine design, cancer neoantigen identification …
order to enable applications such as vaccine design, cancer neoantigen identification …
Wnt activation promotes memory T cell polyfunctionality via epigenetic regulator PRMT1
T cell polyfunctionality is a hallmark of protective immunity against pathogens and cancer,
yet the molecular mechanism governing it remains mostly elusive. We found that canonical …
yet the molecular mechanism governing it remains mostly elusive. We found that canonical …
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin
HD Hickman, GV Reynoso, BF Ngudiankama… - Cell host & …, 2013 - cell.com
Despite extensive ex vivo investigation, the spatiotemporal organization of immune cells
interacting with virus-infected cells in tissues remains uncertain. To address this, we used …
interacting with virus-infected cells in tissues remains uncertain. To address this, we used …
Gastrointestinal Microbiome Dysbiosis in Infant Mice Alters Peripheral CD8+ T Cell Receptor Signaling
G Gonzalez-Perez, ESN Lamousé-Smith - Frontiers in Immunology, 2017 - frontiersin.org
We recently reported that maternal antibiotic treatment (MAT) of mice in the last days of
pregnancy and during lactation dramatically alters the density and composition of the …
pregnancy and during lactation dramatically alters the density and composition of the …
Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process
M Bossowska-Nowicka, MB Mielcarska… - BMC microbiology, 2019 - Springer
Background Cathepsins are a group of endosomal proteases present in many cells
including dendritic cells (DCs). The activity of cathepsins is regulated by their endogenous …
including dendritic cells (DCs). The activity of cathepsins is regulated by their endogenous …
Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading
KS Forsyth, NH Roy, E Peauroi, BC DeHaven… - PLoS …, 2020 - journals.plos.org
Smallpox and monkeypox pose severe threats to human health. Other orthopoxviruses are
comparably virulent in their natural hosts, including ectromelia, the cause of mousepox …
comparably virulent in their natural hosts, including ectromelia, the cause of mousepox …
Impact of Distinct Poxvirus Infections on the Specificities and Functionalities of CD4+ T Cell Responses
NA Siciliano, AR Hersperger, AM Lacuanan… - Journal of …, 2014 - Am Soc Microbiol
The factors that determine CD4+ T cell (TCD4+) specificities, functional capacity, and
memory persistence in response to complex pathogens remain unclear. We explored these …
memory persistence in response to complex pathogens remain unclear. We explored these …
[HTML][HTML] Interaction between unrelated viruses during in vivo co-infection to limit pathology and immunity
MS McAfee, TP Huynh, JL Johnson, BL Jacobs… - Virology, 2015 - Elsevier
Great progress has been made in understanding immunity to viral infection. However,
infection can occur in the context of co-infection by unrelated pathogens that modulate …
infection can occur in the context of co-infection by unrelated pathogens that modulate …
Epithelial Immunization Induces Polyfunctional CD8+ T Cells and Optimal Mousepox Protection
AR Hersperger, NA Siciliano, BC DeHaven… - Journal of …, 2014 - Am Soc Microbiol
We assessed several routes of immunization with vaccinia virus (VACV) in protecting mice
against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest …
against ectromelia virus (ECTV). By a wide margin, skin scarification provided the greatest …