Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Neutrophils are the major circulating white blood cells in humans. They play an essential
role in host defense against pathogens. In healthy individuals, circulating neutrophils are in …

Exposure to pro-inflammatory cytokines, chemokines, mitochondrial contents, and bacterial
and viral products induces neutrophils to transition from a basal state into a primed one …

Neutrophil NET formation induced by PMA, bacteria, and ionomycin has different
requirements for NADPH oxidase activity and myeloperoxidase. Release of NETs by …

Formyl peptide receptors (FPRs) are a small group of seven-transmembrane domain, G
protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes …

Staphylococcus aureus has been an important human pathogen throughout history and is
currently a leading cause of bacterial infections worldwide. S. aureus has the unique ability …

Phosphoinositide 3-kinase (PI3K) activity is crucial for leukocyte function, but the roles of the
four receptor-activated isoforms are unclear. Mice lacking heterotrimeric guanine nucleotide …

Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular
mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by …

Increased oxidative stress plays an important role in the pathophysiology of cardiovascular
diseases such as hypertension, atherosclerosis, diabetes, cardiac hypertrophy, heart failure …