ClpXP is a AAA+ protease that uses the energy of ATP binding and hydrolysis to perform
mechanical work during targeted protein degradation within cells. ClpXP consists of …

In this paper we review the current status of high-performance computing applications in the
general area of drug discovery. We provide an introduction to the methodologies applied at …

YAP is a mechanosensitive transcriptional activator with a critical role in cancer,
regeneration, and organ size control. Here, we show that force applied to the nucleus …

▪ Abstract Mechanical processes are involved in nearly every facet of the cell cycle.
Mechanical forces are generated in the cell during processes as diverse as chromosomal …

Cells interpret mechanical stimuli from their environments and neighbors, but the ability to
engineer customized mechanosensing capabilities has remained a synthetic and …

In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

Background—Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited
genetic myocardial disease characterized by fibrofatty replacement of the myocardium and a …

Here we review the applications of atomic force microscopy to the study of samples of
biological origin. Emphasis is given to provide the reader with information on the broad …

All-atom molecular dynamics simulations have become increasingly popular as a tool to
investigate protein function and dynamics. However, researchers are concerned about the …

Ubiquitin chains are formed through the action of a set of enzymes that covalently link
ubiquitin either through peptide bonds or through isopeptide bonds between their C …