The role of neutrophils in host defense and disease
Neutrophils, the most abundant circulating leukocyte, are critical for host defense.
Granulopoiesis is under the control of transcriptional factors and culminates in mature …
Granulopoiesis is under the control of transcriptional factors and culminates in mature …
Involvement of CXCR4 in normal and abnormal development
N Kawaguchi, TT Zhang, T Nakanishi - Cells, 2019 - mdpi.com
CXC motif chemokine receptor type 4 (CXCR4) is associated with normal and abnormal
development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …
development, including oncogenesis. The ligand of CXCR4 is stromal cell-derived factor …
A phase III randomized crossover trial of plerixafor versus G-CSF for treatment of WHIM syndrome
DH McDermott, D Velez, E Cho… - The Journal of …, 2023 - Am Soc Clin Investig
BACKGROUND Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM)
syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function …
syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function …
Clinical significance of chemokine receptor antagonists
M Miao, E De Clercq, G Li - Expert Opinion on Drug Metabolism & …, 2020 - Taylor & Francis
Introduction: Chemokine receptors are important therapeutic targets for the treatment of
many human diseases. This study will provide an overview of approved chemokine receptor …
many human diseases. This study will provide an overview of approved chemokine receptor …
[HTML][HTML] Relevance of the CXCR4/CXCR7-CXCL12 axis and its effect in pathophysiological conditions
C Huynh, J Dingemanse… - Pharmacological …, 2020 - Elsevier
The impact of the CXC receptor (CXCR) 7 and its close co-player CXCR4 in different
physiological and pathophysiological processes has been extensively investigated within …
physiological and pathophysiological processes has been extensively investigated within …
Chemokines in COPD: from implication to therapeutic use
Chronic Obstructive Pulmonary Disease (COPD) represents the 3rd leading cause of death
in the world. The underlying pathophysiological mechanisms have been the focus of …
in the world. The underlying pathophysiological mechanisms have been the focus of …
WHIM syndrome: from pathogenesis towards personalized medicine and cure
WHIM syndrome is a rare combined primary immunodeficiency disease named by acronym
for the diagnostic tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis …
for the diagnostic tetrad of warts, hypogammaglobulinemia, infections, and myelokathexis …
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases
Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and
targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin …
targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin …
Macrophage exclusion after radiation therapy (MERT): a first in human phase I/II trial using a CXCR4 inhibitor in glioblastoma
Purpose: Preclinical studies have demonstrated that postirradiation tumor revascularization
is dependent on a stromal cell–derived factor-1 (SDF-1)/CXC chemokine receptor type 4 …
is dependent on a stromal cell–derived factor-1 (SDF-1)/CXC chemokine receptor type 4 …
The secretive life of neutrophils revealed by intravital microscopy
K De Filippo, SM Rankin - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Neutrophils are the most abundant circulating leukocyte within the blood stream and for
many years the dogma has been that these cells migrate rapidly into tissues in response to …
many years the dogma has been that these cells migrate rapidly into tissues in response to …