In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …

We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …

Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …

Lung transplantation is the most effective therapy for patients with end-stage lung disease.
However, concern of donor lung damage and ischemia-reperfusion induced lung injury …

The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …

The endoplasmic reticulum (ER) is an important organelle that regulates several
fundamental cellular processes, and ER dysfunction has implications for many intracellular …

Background/Aims: Angiotensin (Ang) II plays vital roles in vascular inflammation and
remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells …

Chronic rejection is the major leading cause of morbidity and mortality after lung
transplantation. Bronchiolitis obliterans syndrome (BOS), a fibroproliferative disorder of the …

Sarcoidosis is a sterile non-necrotizing granulomatous disease without known causes that
can involve multiple organs with a predilection for the lung and thoracic lymph nodes …