Damage-associated molecular patterns in myocardial infarction and heart transplantation: the road to translational success
MJM Silvis, SE Kaffka genaamd Dengler… - Frontiers in …, 2020 - frontiersin.org
In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …
Activation of immune signals during organ transplantation
Q Li, P Lan - Signal transduction and targeted therapy, 2023 - nature.com
The activation of host's innate and adaptive immune systems can lead to acute and chronic
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …
graft rejection, which seriously impacts graft survival. Thus, it is particularly significant to …
Cannabidiol prevents LPS‐induced microglial inflammation by inhibiting ROS/NF‐κB‐dependent signaling and glucose consumption
M dos‐Santos‐Pereira, FS Guimaraes, E Del‐Bel… - Glia, 2020 - Wiley Online Library
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …
study the anti‐inflammatory potential of cannabidiol (CBD), the major nonpsychoactive …
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
S Malhotra, C Costa, H Eixarch, CW Keller, L Amman… - Brain, 2020 - academic.oup.com
Primary progressive multiple sclerosis is a poorly understood disease entity with no specific
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
prognostic biomarkers and scarce therapeutic options. We aimed to identify disease activity …
Cell death and ischemia-reperfusion injury in lung transplantation
M Capuzzimati, O Hough, M Liu - The Journal of Heart and Lung …, 2022 - Elsevier
Lung transplantation is the most effective therapy for patients with end-stage lung disease.
However, concern of donor lung damage and ischemia-reperfusion induced lung injury …
However, concern of donor lung damage and ischemia-reperfusion induced lung injury …
Infectious complications of biological and small molecule targeted immunomodulatory therapies
The past 2 decades have seen a revolution in our approach to therapeutic
immunosuppression. We have moved from relying on broadly active traditional medications …
immunosuppression. We have moved from relying on broadly active traditional medications …
ER stress activates the NLRP3 inflammasome: a novel mechanism of atherosclerosis
X Chen, X Guo, Q Ge, Y Zhao, H Mu… - Oxidative Medicine and …, 2019 - Wiley Online Library
The endoplasmic reticulum (ER) is an important organelle that regulates several
fundamental cellular processes, and ER dysfunction has implications for many intracellular …
fundamental cellular processes, and ER dysfunction has implications for many intracellular …
[HTML][HTML] NLRP3 gene deletion attenuates angiotensin II-induced phenotypic transformation of vascular smooth muscle cells and vascular remodeling
Background/Aims: Angiotensin (Ang) II plays vital roles in vascular inflammation and
remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells …
remodeling in hypertension. Phenotypic transformation of vascular smooth muscle cells …
Modulation of NLRP3 inflammasome through formyl peptide receptor 1 (Fpr-1) pathway as a new therapeutic target in bronchiolitis obliterans syndrome
Chronic rejection is the major leading cause of morbidity and mortality after lung
transplantation. Bronchiolitis obliterans syndrome (BOS), a fibroproliferative disorder of the …
transplantation. Bronchiolitis obliterans syndrome (BOS), a fibroproliferative disorder of the …
[HTML][HTML] Pulmonary sarcoidosis: a comprehensive review: past to present
JA Belperio, MC Fishbein, F Abtin, J Channick… - Journal of …, 2023 - Elsevier
Sarcoidosis is a sterile non-necrotizing granulomatous disease without known causes that
can involve multiple organs with a predilection for the lung and thoracic lymph nodes …
can involve multiple organs with a predilection for the lung and thoracic lymph nodes …