Interconnected functional strategies govern chromatin dynamics in eukaryotic cells. In this
context, A and B type lamins, the nuclear intermediate filaments, act on diverse platforms …

Type 2 familial partial lipodystrophy (FPLD2) is a laminopathic lipodystrophy due to
pathogenic variants in the LMNA gene. Its rarity implies that it is not well-known. The aim of …

Lamin A/C proteins are the major components of a thin proteinaceous filamentous
meshwork, the lamina, that underlies the inner nuclear membrane. A few specific mutations …

Mandibuloacral dysplasia (MAD) is a rare genetic condition characterized by bone
abnormalities including localized osteolysis and generalized osteoporosis, skin …

Laminopathies are genetic diseases due to mutations or altered post‐translational
processing of nuclear envelope/lamina proteins. The majority of laminopathies are caused …

Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation
pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a …

The current epidemic of obesity has brought to light the role of adipose tissue as an active
endocrine organ in the regulation of energy homeostasis. Adipose tissue secretes a large …

Adipose tissue represents a complex tissue both in terms of its cellular composition, as it
includes mature adipocytes and the various cell types comprising the stromal‐vascular …

Severe insulin resistance syndromes are a heterogeneous group of rare disorders
characterized by profound insulin resistance, substantial metabolic abnormalities, and a …

Several alterations in nuclear envelope proteins building up the lamina meshwork beneath
the inner nuclear membrane (mutations in lamins A/C, alterations of prelamin-A maturation …