Background Tuberculosis, caused by bacteria in the Mycobacterium tuberculosis complex
(MTBC), is a major global public health burden. Strain-specific genomic diversity in the …

The emergence of drug-resistant tuberculosis is a major global public health concern that
threatens the ability to control the disease. Whole-genome sequencing as a tool to rapidly …

In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …

Abstract Multi-Drug-Resistant strains of Mycobacterium tuberculosis (MDR-TB) are a serious
obstacle to global TB eradication. While most MDR-TB strains are infrequently transmitted, a …

Mycobacterium tuberculosis (Mtb) acquires drug resistance at a rate comparable to that of
bacterial pathogens that replicate much faster and have a higher mutation rate. One …

Fluoroquinolones (FQ) form the backbone in experimental treatment regimens against drug-
susceptible tuberculosis. However, little is known on whether the genetic variation present in …

Abstract Background Drug resistant Mycobacterium tuberculosis prevention and care is a
major challenge in Ethiopia. The World health organization has designated Ethiopia as one …

Tuberculosis, caused by Mycobacterium tuberculosis, is a high-burden disease in Pakistan,
with multi-drug (MDR) and extensive-drug (XDR) resistance, complicating infection control …

Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from
bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline …

Bacterial strain-types in the Mycobacterium tuberculosis complex underlie tuberculosis
disease, and have been associated with drug resistance, transmissibility, virulence, and host …