The development of animal embryos is initially directed by maternal gene products. Then,
during the maternal-to-zygotic transition (MZT), developmental control is handed to the …

The first major developmental transition in vertebrate embryos is the maternal-to-zygotic
transition (MZT) when maternal mRNAs are degraded and zygotic transcription begins …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

To explore the origins and consequences of tetraploidy in the African clawed frog, we
sequenced the Xenopus laevis genome and compared it to the related diploid X. tropicalis …

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a conserved post-transcriptional
mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering …

Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

Background High-throughput transcriptome sequencing (RNA-seq) technology promises to
discover novel protein-coding and non-coding transcripts, particularly the identification of …

We have produced an mRNA expression time course of zebrafish development across 18
time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos …

Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development …

CRISPR–Cas9 has emerged as a powerful technology that enables ready modification of
the mammalian genome. The ability to modulate Cas9 activity can reduce off-target …