Dioxins are ubiquitous and persistent environmental contaminants whose background
levels are still reason for concern. There is mounting evidence from both epidemiological …

The E2F transcription factor family, a cellular factor required for activation of the E2
adenoviral promoter (1), came to the forefront of cancer research when it was found to be …

The MADS box transcription factor RIN is a global regulator of fruit ripening. However, the
direct targets modulated by RIN and the mechanisms underlying the transcriptional …

Anabolism and catabolism are tightly regulated according to the cellular energy supply.
Upon energy stress, ribosomal RNA (rRNA) biogenesis is inhibited, and autophagy is …

Background: E2F2 is a member of the E2F transcription factor family and has important but
not fully understood biological functions in cancers. The biological role of E2F2 in gastric …

Abstract MicroRNA-31 (miR-31) plays important roles in colon cancer development.
However, the underlying mechanism is still not clear. We have explored the functions of miR …

Endothelial cell senescence has a vital implication for vascular dysfunction, leading to age-
related cardiovascular disease, especially hypertension and atherosclerosis. E2F …

Abstract 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) is a well-known immunotoxic
environmental pollutant. However, most immunotoxicology studies of TCDD were based on …

While activation of the aryl hydrocarbon receptor (AhR) by exogenous ligands is well
investigated, its physiological function is less understood. By extending research in AhR …

Cancer occurrence and development are closely related to the environment. Aryl
hydrocarbon receptor (AhR) is an important receptor mediating the toxic effects of many …