The arms race between bacteria and their phage foes
HG Hampton, BNJ Watson, PC Fineran - Nature, 2020 - nature.com
Bacteria are under immense evolutionary pressure from their viral invaders—
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
Pseudomonas predators: understanding and exploiting phage–host interactions
J De Smet, H Hendrix, BG Blasdel… - Nature Reviews …, 2017 - nature.com
Species in the genus Pseudomonas thrive in a diverse set of ecological niches and include
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …
crucial pathogens, such as the human pathogen Pseudomonas aeruginosa and the plant …
Drivers and consequences of bacteriophage host range
D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
The preclinical and clinical progress of bacteriophages and their lytic enzymes: the parts are easier than the whole
The therapeutic potential of phages has been considered since their first identification more
than a century ago. The evident concept of using a natural predator to treat bacterial …
than a century ago. The evident concept of using a natural predator to treat bacterial …
High coverage metabolomics analysis reveals phage-specific alterations to Pseudomonas aeruginosa physiology during infection
Phage-mediated metabolic changes in bacteria are hypothesized to markedly alter global
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
nutrient and biogeochemical cycles. Despite their theoretic importance, experimental data …
Exploring the synthetic biology potential of bacteriophages for engineering non-model bacteria
Non-model bacteria like Pseudomonas putida, Lactococcus lactis and other species have
unique and versatile metabolisms, offering unique opportunities for Synthetic Biology …
unique and versatile metabolisms, offering unique opportunities for Synthetic Biology …
Metabolic reprogramming of Pseudomonas aeruginosa by phage-based quorum sensing modulation
H Hendrix, M Zimmermann-Kogadeeva… - Cell Reports, 2022 - cell.com
The Pseudomonas quinolone signal (PQS) is a multifunctional quorum sensing molecule of
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …
key importance to P. aeruginosa. Here, we report that the lytic Pseudomonas bacterial virus …
Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa
E Sonnleitner, A Wulf, S Campagne, XY Pei… - Nucleic acids …, 2018 - academic.oup.com
In Pseudomonas aeruginosa the RNA chaperone Hfq and the c atabolite r epression c ontrol
protein (Crc) act as post-transcriptional regulators during carbon catabolite repression …
protein (Crc) act as post-transcriptional regulators during carbon catabolite repression …
Phage-derived antibacterials: harnessing the simplicity, plasticity, and diversity of phages
B Kim, ES Kim, YJ Yoo, HW Bae, IY Chung, YH Cho - Viruses, 2019 - mdpi.com
Despite the successful use of antibacterials, the emergence of multidrug-resistant bacteria
has become a serious threat to global healthcare. In this era of antibacterial crisis …
has become a serious threat to global healthcare. In this era of antibacterial crisis …
[HTML][HTML] Phage-based target discovery and its exploitation towards novel antibacterial molecules
Highlights•Understanding phage hijacking mechanism can facilitate the discovery of novel
antibacterials.•Phage genome-driven screening can reveal novel bacterial targets for small …
antibacterials.•Phage genome-driven screening can reveal novel bacterial targets for small …