Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors
for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological …

Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as
an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in …

Despite a wealth of clinical data showing an association between inflammation and
degenerative disorders in the elderly, the immune sensors that causally link systemic …

Recent research has demonstrated that survivors of childhood cancer are at risk for a myriad
of late effects that affect physical and mental quality of life. We discuss the patterns and …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …

Trained immunity is a process in which innate immune cells undergo functional
reprogramming in response to pathogens or damage‐associated molecules leading to an …

Many animal models have been developed to study the causes and treatments of chronic
kidney disease (CKD) in humans, an insidious disease resulting from kidney injury and …

Asymptomatic hyperuricaemia affects~ 20% of the general population in the USA, with
variable rates in other countries. Historically, asymptomatic hyperuricaemia was considered …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …

High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a
strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for …