An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks

N Hofer, E Zacharias, W Müller, B Resch - Neonatology, 2012 - karger.com
C-reactive protein (CRP) is one of the most studied and most used laboratory tests for
neonatal sepsis. As part of the acute-phase reaction to infection, it plays a central role in the …

The developing immune system–from foetus to toddler

S Ygberg, A Nilsson - Acta paediatrica, 2012 - Wiley Online Library
During foetal development, neonatal period and childhood, the immune system is constantly
maturing. In the foetus, infection responsiveness is low and associates with spontaneous …

Application of electronic-nose technologies and VOC-biomarkers for the noninvasive early diagnosis of gastrointestinal diseases

AD Wilson - Sensors, 2018 - mdpi.com
Conventional methods utilized for clinical diagnosis of gastrointestinal (GI) diseases have
employed invasive medical procedures that cause stress, anxiety and pain to patients …

Pathophysiology and treatment of septic shock in neonates

JL Wynn, HR Wong - Clinics in perinatology, 2010 - perinatology.theclinics.com
Sepsis or serious infection within the first 4 weeks of life kills more than 1 million newborns
globally every year. 1 The attack rate for neonatal sepsis is variable (from< 1% to> 35% of …

Translational research and biomarkers in neonatal sepsis

JR Delanghe, MM Speeckaert - Clinica chimica acta, 2015 - Elsevier
As neonatal sepsis is a severe condition, there is a call for reliable biomarkers to
differentiate between infected and noninfected newborns. Although blood culture has been …

Association of inflammatory biomarkers with subsequent clinical course in suspected late onset sepsis in preterm neonates

Ş Kurul, SHP Simons, CRB Ramakers, YB De Rijke… - Critical Care, 2021 - Springer
Background Sepsis is a major health issue in preterm infants. Biomarkers are used to
diagnose and monitor patients with sepsis, but C-reactive protein (CRP) is proven not …

Diagnostic tests in neonatal sepsis

S Arnon, I Litmanovitz - Current opinion in infectious diseases, 2008 - journals.lww.com
A better understanding of the neonatal inflammatory response to sepsis and identification of
sensitive and specific markers of inflammation or rapid microbe-specific diagnostic tests …

Host-response biomarkers for diagnosis of late-onset septicemia and necrotizing enterocolitis in preterm infants

PC Ng, IL Ang, RWK Chiu, K Li, HS Lam… - The Journal of …, 2010 - Am Soc Clin Investig
Preterm infants are highly susceptible to life-threatening infections that are clinically difficult
to detect, such as late-onset septicemia and necrotizing enterocolitis (NEC). Here, we used …

Biomarkers for the diagnosis of neonatal sepsis and necrotizing enterocolitis: Clinical practice guidelines

M Gilfillan, V Bhandari - Early human development, 2017 - Elsevier
Sepsis and necrotizing enterocolitis are major contributors to morbidity and mortality in
neonates, especially in those born preterm. While therapeutic interventions are available for …

[HTML][HTML] Evaluation of IL-6, CRP and hs-CRP as early markers of neonatal sepsis

P Ganesan, P Shanmugam, SBA Sattar… - Journal of clinical and …, 2016 - ncbi.nlm.nih.gov
Aim This study aimed to detect the levels of IL-6, CRP and hs-CRP in clinically suspected
cases of neonatal sepsis and to evaluate and analyze the above parameters as the early …