Multienzyme‐like nanozymes: regulation, rational design, and application

J Sheng, Y Wu, H Ding, K Feng, Y Shen… - Advanced …, 2024 - Wiley Online Library
Nanomaterials with more than one enzyme‐like activity are termed multienzymic
nanozymes, and they have received increasing attention in recent years and hold huge …

Design of therapeutic biomaterials to control inflammation

Z Tu, Y Zhong, H Hu, D Shao, R Haag… - Nature Reviews …, 2022 - nature.com
Inflammation plays an important role in the response to danger signals arising from damage
to our body and in restoring homeostasis. Dysregulated inflammatory responses occur in …

“Electron transport chain interference” strategy of amplified mild-photothermal therapy and defect-engineered multi-enzymatic activities for synergistic tumor …

S Dong, Y Dong, Z Zhao, J Liu, S Liu… - Journal of the …, 2023 - ACS Publications
Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor
thermotolerance holds great promise for overcoming traditional mild PTT limitations such as …

Catalase‐like nanozymes: Classification, catalytic mechanisms, and their applications

D Xu, L Wu, H Yao, L Zhao - Small, 2022 - Wiley Online Library
The field of nanozymes has developed rapidly over the past decade. Among various
oxidoreductases mimics, catalase (CAT)‐like nanozyme, acting as an essential part of the …

Bioinspired copper single‐atom nanozyme as a superoxide dismutase‐like antioxidant for sepsis treatment

J Yang, R Zhang, H Zhao, H Qi, J Li, JF Li, X Zhou… - …, 2022 - Wiley Online Library
Sepsis is a systemic inflammatory response syndrome with high morbidity and mortality
mediated by infection‐caused oxidative stress. Early antioxidant intervention by removing …

Recent advances in nanozymes: from matters to bioapplications

Y Ai, ZN Hu, X Liang, H Sun, H Xin… - Advanced Functional …, 2022 - Wiley Online Library
The manufacture of bionic materials to simulate the natural counterparts has attracted
extensive attention. As one of the subcategories of biomimetic materials, the development of …

Ceria‐based therapeutic antioxidants for biomedical applications

YG Kim, Y Lee, N Lee, M Soh, D Kim… - Advanced …, 2024 - Wiley Online Library
The growing interest in nanomedicine over the last 20 years has carved out a research field
called “nanocatalytic therapy,” where catalytic reactions mediated by nanomaterials are …

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

W Feng, X Han, H Hu, M Chang, L Ding… - Nature …, 2021 - nature.com
Reactive oxygen species (ROS) are generated and consumed in living organism for normal
metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

GSH‐depleted nanozymes with hyperthermia‐enhanced dual enzyme‐mimic activities for tumor nanocatalytic therapy

S Dong, Y Dong, T Jia, S Liu, J Liu, D Yang… - Advanced …, 2020 - Wiley Online Library
Nanocatalytic therapy, using artificial nanoscale enzyme mimics (nanozymes), is an
emerging technology for therapeutic treatment of various malignant tumors. However, the …