Lipid droplets (also known as lipid bodies) are lipid-rich, cytoplasmic organelles that play
important roles in cell signaling, lipid metabolism, membrane trafficking, and the production …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …

A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …

Mammalian lipid droplets (LDs) are specialized cytosolic organelles consisting of a neutral
lipid core surrounded by a membrane made up of a phospholipid monolayer and a specific …

Induction of ferroptosis is an emerging strategy to suppress melanoma progression.
Strategies to enhance the sensitivity to ferroptosis induction would be a major advance in …

We report a comprehensive proteomic study of a 90-case cohort of paired samples of triple-
negative breast cancer (TNBC) in quantification, phosphorylation, and DNA-binding …

Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Mammalian target of rapamycin (mTOR) regulates various fundamental cellular events
including cell proliferation, protein synthesis, metabolism, apoptosis, and autophagy. Tumor …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …