The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The
evolutionary pressure associated with establishing and maintaining an infection and …

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the
flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a …

Trypanosomes have complex life cycles within which there are both proliferative and
differentiation cell divisions. The coordination of the cell cycle to achieve these different …

The unicellular trypanosomatids belong to the phylum Euglenozoa and all known species
are obligate parasites. Distinct lineages infect plants, invertebrates, and vertebrates …

Leishmania kinetoplastid parasites infect millions of people worldwide and have a distinct
cellular architecture depending on location in the host or vector and specific pathogenicity …

The subpellicular microtubule array defines the wide range of cellular morphologies found in
parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array …

Several models have been proposed to explain how eukaryotic cells control the length of
their cilia and flagella. Here, we investigated this process in the protist Trypanosoma brucei …

In the unicellular parasite Trypanosoma brucei, the causative agent of human African
sleeping sickness, complex swimming behavior is driven by a flagellum laterally attached to …

While flagella have been studied extensively as motility organelles, with a focus on internal
structures such as the axoneme, more recent research has illuminated the roles of the …

The Leishmania donovani species complex is the causative agent of visceral leishmaniasis,
which cause 20–40,000 fatalities a year. Here, we conduct a screen for balancing selection …