Uncontrolled cell proliferation is the hallmark of cancer, and tumor cells have typically
acquired damage to genes that directly regulate their cell cycles. Genetic alterations …

In multicellular organisms, cell proliferation and death must be regulated to maintain tissue
homeostasis. Many observations suggest that this regulation may be achieved, in part, by …

Myostatin, a member of the transforming growth factor-β (TGF-β) superfamily, has been
shown to be a negative regulator of myogenesis. Here we show that myostatin functions by …

We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates
successive intramolecular interactions between the C-terminal region and the central …

All eukaryotic cells possess similar mechanisms to regulate the progression of the cell cycle,
However, higher eukaryotes have evolved to respond to a large array of positive and …

Geminiviruses have small, single-stranded DNA genomes that replicate through double-
stranded intermediates in the nuclei of infected plant cells. Viral double-stranded DNA also …

▪ Abstract Tissue homeostasis requires a balance between cell proliferation and death.
Apoptosis and proliferation are linked by cell cycle regulators, and apoptotic stimuli affect …

Previously, we found that Rb can actively repress transcription of cell cycle genes by binding
and inactivating transcription factors at the promoter. Here, we demonstrate that Rb can also …

We present evidence that Rb forms a repressor containing histone deacetylase (HDAC) and
the hSWI/SNF nucleosome remodeling complex, which inhibits transcription of genes for …

mRNA transcription, DNA amplification, and progeny production of human papillomaviruses
(HPVs) are closely linked to squamous epithelial differentiation in patient papillomas …