RASSF1A: A promising target for the diagnosis and treatment of cancer
Y Bin, Y Ding, W Xiao, A Liao - Clinica Chimica Acta, 2020 - Elsevier
The Ras association domain family 1 isoform A (RASSF1A), a tumor suppressor, regulates
several tumor-related signaling pathways and interferes with diverse cellular processes …
several tumor-related signaling pathways and interferes with diverse cellular processes …
JAZF1 suppresses papillary thyroid carcinoma cell proliferation and facilitates apoptosis via regulating TAK1/NF-κB pathways
L Huang, Y Cai, Y Luo, D Xiong, Z Hou, J Lv… - OncoTargets and …, 2019 - Taylor & Francis
Purpose Juxtaposed with another zinc finger gene 1 (JAZF1) is involved in
gluconeogenesis, insulin sensitivity, cell differentiation, lipid metabolism and inflammation …
gluconeogenesis, insulin sensitivity, cell differentiation, lipid metabolism and inflammation …
[HTML][HTML] The Effect of 5-aza, 2'-deoxyCytidine (5 AZA CdR or Decitabine) on Extrinsic, Intrinsic, and JAK/STAT Pathways in Neuroblastoma and Glioblastoma Cells …
Epigenetic changes such as histone deacetylation and DNA methylation play to regulate
gene expression. DNA methylation plays a major role in cancer induction via transcriptional …
gene expression. DNA methylation plays a major role in cancer induction via transcriptional …
[HTML][HTML] Knockdown of DNMT1 Induces SLCO3A1 to Promote Follicular Growth by Enhancing the Proliferation of Granulosa Cells in Mammals
S Li, L Zeng, F Miao, N Li, W Liao, X Zhou… - International Journal of …, 2024 - mdpi.com
In female mammals, the proliferation and apoptosis of granulosa cells (GCs) have been
shown to determine the fate of follicles. DNA methyltransferases (DNMTs) and SLCO3A1 …
shown to determine the fate of follicles. DNA methyltransferases (DNMTs) and SLCO3A1 …
5-Aza-Cdr regulates RASSF1a by inhibiting DNMT1 to affect colon cancer cell proliferation, migration and apoptosis
J Chen, L Wu, H Xu, S Cheng - Cancer Management and Research, 2019 - Taylor & Francis
Objective To evaluate 5-Aza-CdR's inhibited effects on migration, proliferation, and
apoptosis in colon cancer cells and its potential mechanisms. Methods HCT-116, SW480 …
apoptosis in colon cancer cells and its potential mechanisms. Methods HCT-116, SW480 …
DNA methylation influences the CTCF‐modulated transcription of RASSF1A in lung cancer cells
B Xie, F Peng, F He, Y Cheng, J Cheng… - Cell Biology …, 2022 - Wiley Online Library
Ras‐association domain family 1A (RASSF1A) is one of the most methylated genes in lung
cancer (LC). We investigate whether the high DNA methylation level of RASSF1A can …
cancer (LC). We investigate whether the high DNA methylation level of RASSF1A can …
DNMT1-mediated Foxp3 gene promoter hypermethylation involved in immune dysfunction caused by arsenic in human lymphocytes
Y Ma, Y Ye, Y Liu, J Chen, Y Cen, W Chen… - Toxicology …, 2020 - academic.oup.com
Growing evidence indicates that arsenic can cause long-lasting and irreversible damage to
the function of the human immune system. It is known that forkhead box protein 3 (Foxp3) …
the function of the human immune system. It is known that forkhead box protein 3 (Foxp3) …
[HTML][HTML] Effect of 5'-fluoro-2'-deoxycytidine and sodium butyrate on the gene expression of the intrinsic apoptotic pathway, p21, p27, and p53 genes expression, cell …
Background: Epigenetic mechanisms play an important role in the regulation of gene
expression and genetic information. DNA methyltransferases are a family of enzymes that …
expression and genetic information. DNA methyltransferases are a family of enzymes that …
CpG Island methylator phenotype modulates the immune response of the tumor microenvironment and influences the prognosis of pancreatic cancer patients
G Ning, Y Li, W Chen, W Tang, D Shou… - Journal of …, 2021 - Wiley Online Library
Background. CpG island methylator phenotype (CIMP), featured with concurrent and
widespread hypermethylation of a cluster of CpGs, has been reported to play an important …
widespread hypermethylation of a cluster of CpGs, has been reported to play an important …
[HTML][HTML] Small molecule inhibitor C188-9 synergistically enhances the demethylated activity of low-dose 5-Aza-2′-deoxycytidine against pancreatic cancer
R Kong, G Sun, X Li, L Wu, L Li, Y Li, F Wang… - Frontiers in …, 2020 - frontiersin.org
Aberrant DNA methylation, especially hypermethylation of tumor suppressor genes, has
been associated with many cancers' progression. 5-Aza-2′-deoxycytidine (DAC) can …
been associated with many cancers' progression. 5-Aza-2′-deoxycytidine (DAC) can …