The mammalian circadian system, which is comprised of multiple cellular clocks located in
the organs and tissues, orchestrates their regulation in a hierarchical manner throughout the …

Sleep homeostasis and circadian function are important maintaining factors for optimal
health and well-being. Conversely, sleep and circadian disruptions are implicated in a …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

The main characteristic of alcohol use disorder is the consumption of large quantities of
alcohol despite the negative consequences. The transition from the moderate use of alcohol …

Many psychiatric disorders are characterized by circadian rhythm abnormalities, including
disturbed sleep/wake cycles, changes in locomotor activity, and abnormal endocrine …

Alcohol is frequently consumed for stress relief, but the individual determinants and the
temporal course of stress-induced alcohol use are not well understood. Preclinical studies …

While stressful experiences are a part of everyone's life, they can also exact a major toll on
health. Stressful life experiences are associated with increased substance abuse, and there …

Circadian rhythms are prominent in many physiological and behavioral functions. Circadian
disruptions either by environmental or molecular perturbation can have profound health …

Background Substance use disorders are associated with disruptions in circadian rhythms.
Both human and animal work have shown the integral role for circadian clocks in the …

Alcoholism and drug dependence are common psychiatric disorders with a heritability of
about 50%; therefore genetic and environmental influences are equally important. Early-life …