Melatonin is an ancient molecule that can be traced back to the origin of life. Melatonin's
initial function was likely that as a free radical scavenger. Melatonin presumably evolved in …

Emerging evidence now indicates that mitochondria are central regulators of neural stem
cell (NSC) fate decisions and are crucial for both neurodevelopment and adult …

The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in
devising potential cell-based therapeutic strategies for central nervous system (CNS) …

The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …

Radiotherapy remains a mainstay of cancer treatment, being used in roughly 50% of
patients. The precision with which the radiation dose can be delivered is rapidly improving …

Acute myocardial infarction (MI) is a major cause of mortality and disability worldwide. In
patients with MI, the treatment option for reducing acute myocardial ischemic injury and …

Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt
mammalian target of rapamycin (mTOR) signalling pathway. However, the effectiveness of …

There is a bidirectional relationship between inflammatory bowel disease (IBD) and
depression/anxiety. Emerging evidences indicate that the liver may be involved in …

The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …