History and progress of hypotheses and clinical trials for Alzheimer's disease
PP Liu, Y Xie, XY Meng, JS Kang - Signal transduction and targeted …, 2019 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
memory loss along with neuropsychiatric symptoms and a decline in activities of daily life. Its …
Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise
F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …
Lifestyle interventions to prevent cognitive impairment, dementia and Alzheimer disease
M Kivipelto, F Mangialasche, T Ngandu - Nature Reviews Neurology, 2018 - nature.com
Research into dementia prevention is of paramount importance if the dementia epidemic is
to be halted. Observational studies have identified several potentially modifiable risk factors …
to be halted. Observational studies have identified several potentially modifiable risk factors …
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …
range of essential and beneficial functions. Our appreciation of the importance of these …
[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease
S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most …
Impact of metabolic syndrome on neuroinflammation and the blood–brain barrier
P Van Dyken, B Lacoste - Frontiers in neuroscience, 2018 - frontiersin.org
Metabolic syndrome, which includes diabetes and obesity, is one of the most widespread
medical conditions. It induces systemic inflammation, causing far reaching effects on the …
medical conditions. It induces systemic inflammation, causing far reaching effects on the …
Stroke and dementia risk: a systematic review and meta-analysis
Introduction Stroke is an established risk factor for all-cause dementia, though meta-
analyses are needed to quantify this risk. Methods We searched Medline, PsycINFO, and …
analyses are needed to quantify this risk. Methods We searched Medline, PsycINFO, and …
The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies
Scope: it has been suggested that overweight/obesity as a risk factor for incident dementia
differs between mid-life and later life. We performed a systematic review and meta-analysis …
differs between mid-life and later life. We performed a systematic review and meta-analysis …
BMI and risk of dementia in two million people over two decades: a retrospective cohort study
N Qizilbash, J Gregson, ME Johnson… - The lancet Diabetes & …, 2015 - thelancet.com
Background Dementia and obesity are increasingly important public health issues. Obesity
in middle age has been proposed to lead to dementia in old age. We investigated the …
in middle age has been proposed to lead to dementia in old age. We investigated the …
Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease
FG De Felice, ST Ferreira - Diabetes, 2014 - Am Diabetes Assoc
A growing body of evidence supports an intriguing clinical/epidemiological connection
between Alzheimer disease (AD) and type 2 diabetes (T2D). T2D patients have significantly …
between Alzheimer disease (AD) and type 2 diabetes (T2D). T2D patients have significantly …