The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

The extracellular matrix (ECM) exists as a dynamic network of biophysical and biochemical
factors that maintain tissue homeostasis. Given its sensitivity to changes in the intra-and …

The cardiac microvascular reperfusion injury is characterized by the microvascular
endothelial cells (CMECs) oxidative damage which is responsible for the progression of …

Biglycan (BGN), a proteoglycan of the extracellular matrix, is included in mRNA signatures
for prostate cancer aggressiveness. To understand the impact of BGN on prognosis and its …

Atrial fibrillation (AF) is a frequent arrhythmia associated with cardiovascular morbidity and
mortality. Neutrophil extracellular traps (NETs) are DNA fragments with cytoplasm proteins …

The need for more effective cancer therapies is omnipresent as the ever-complex, and
highly adaptive, mechanisms of tumor biology allow this disease to elude even the most …

Prediabetes is a condition affecting more than 35% of the population. In some forms,
excessive carbohydrate intake (primarily refined sugar) plays a prominent role. Prediabetes …

Chronic kidney disease (CKD) is a public health problem that increases the risk of
cardiovascular morbidity and mortality. Heart failure with preserved ejection fraction (HFpEF) …

Background: A deleterious, late-onset side effect of thoracic radiotherapy is the development
of radiation-induced heart disease (RIHD). It covers a spectrum of cardiac pathology …

The extracellular matrix encompasses a reservoir of bioactive macromolecules that
modulates a cornucopia of biological functions. A prominent body of work posits matrix …