Placental origins of chronic disease

GJ Burton, AL Fowden… - Physiological …, 2016 - journals.physiology.org
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Early developmental conditioning of later health and disease: physiology or pathophysiology?

MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …

[HTML][HTML] Endothelial dysfunction and preeclampsia: role of oxidative stress

LC Sánchez-Aranguren, CE Prada… - Frontiers in …, 2014 - frontiersin.org
Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria
at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is …

Nutrition in early life and the programming of adult disease: a review

SC Langley‐Evans - Journal of Human Nutrition and Dietetics, 2015 - Wiley Online Library
Foetal development and infancy are life stages that are characterised by rapid growth,
development and maturation of organs and systems. Variation in the quality or quantity of …

Effect of in utero and early-life conditions on adult health and disease

PD Gluckman, MA Hanson, C Cooper… - New England journal …, 2008 - Mass Medical Soc
Many lines of evidence, including epidemiologic data and extensive clinical and
experimental studies, indicate that early life events play a powerful role in influencing later …

Fetal nutrition and cardiovascular disease in adult life

DJP Barker, KM Godfrey, PD Gluckman, JE Harding… - The Lancet, 1993 - Elsevier
Babies who are small at birth or during infancy have increased rates of cardiovascular
disease and non-insulin-dependent diabetes as adults. Some of these babies have low …

Epigenetic gene promoter methylation at birth is associated with child's later adiposity

KM Godfrey, A Sheppard, PD Gluckman… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity.
In animal models, maternal diet alters offspring body composition, accompanied by …

Ten putative contributors to the obesity epidemic

EJ McAllister, NV Dhurandhar, SW Keith… - Critical reviews in …, 2009 - Taylor & Francis
The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Living with the past: evolution, development, and patterns of disease

PD Gluckman, MA Hanson - Science, 2004 - science.org
Epidemiological observations have led to the hypothesis that the risk of developing some
chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult …

[HTML][HTML] Protein–which is best?

JR Hoffman, MJ Falvo - Journal of sports science & medicine, 2004 - ncbi.nlm.nih.gov
Protein intake that exceeds the recommended daily allowance is widely accepted for both
endurance and power athletes. However, considering the variety of proteins that are …