HIV-1 RNA genome packaging: it's G-rated
A Duchon, WS Hu - Mbio, 2024 - Am Soc Microbiol
ABSTRACT A member of the Retroviridae, human immunodeficiency virus type 1 (HIV-1),
uses the RNA genome packaged into nascent virions to transfer genetic information to its …
uses the RNA genome packaged into nascent virions to transfer genetic information to its …
Role of RNA structural plasticity in modulating HIV-1 genome packaging and translation
HIV-1 transcript function is controlled in part by twinned transcriptional start site usage,
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …
where 5′ capped RNAs beginning with a single guanosine (1G) are preferentially …
Transcription start site choice regulates HIV-1 RNA conformation and function
K Musier-Forsyth, A Rein, WS Hu - Current Opinion in Structural Biology, 2024 - Elsevier
HIV-1, the causative agent of AIDS, is a retrovirus that packages two copies of unspliced
viral RNA as a dimer into newly budding virions. The unspliced viral RNA also serves as an …
viral RNA as a dimer into newly budding virions. The unspliced viral RNA also serves as an …
HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion
K GC, S Lesko, AL Emery, C Burnett, K Gopal, S Clark… - bioRxiv, 2024 - biorxiv.org
HIV-1 transcription initiates at two positions, generating RNAs with either cap1G or cap3G
5′ ends. The replication fates of these RNAs differ, with viral particles encapsidating almost …
5′ ends. The replication fates of these RNAs differ, with viral particles encapsidating almost …
Determinants of Human Immunodeficiency Virus Plasma Viremia
AA Capoferri - 2023 - search.proquest.com
Abstract The Human Immunodeficiency Virus Type 1 (HIV-1) pandemic has resulted in 36.3
million deaths to date. In 2022, 39 million people were living with HIV (PLWH) worldwide …
million deaths to date. In 2022, 39 million people were living with HIV (PLWH) worldwide …