Chagas' disease

C Bern - New England Journal of Medicine, 2015 - Mass Medical Soc
Chagas’ Disease | New England Journal of Medicine Skip to main content The New England
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Chagas disease

JA Pérez-Molina, I Molina - The Lancet, 2018 - thelancet.com
Chagas disease is an anthropozoonosis from the American continent that has spread from
its original boundaries through migration. It is caused by the protozoan Trypanosoma cruzi …

Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled …

F Torrico, J Gascon, L Ortiz, C Alonso-Vega… - The Lancet Infectious …, 2018 - thelancet.com
Background Chagas disease is a major neglected vector-borne disease. In this study, we
investigated the safety and efficacy of three oral E1224 (a water-soluble ravuconazole …

[HTML][HTML] Drug repurposing and human parasitic protozoan diseases

KT Andrews, G Fisher, TS Skinner-Adams - International Journal for …, 2014 - Elsevier
Parasitic diseases have an enormous health, social and economic impact and are a
particular problem in tropical regions of the world. Diseases caused by protozoa and …

[HTML][HTML] Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure

FJ Sánchez-Valdéz, A Padilla, W Wang, D Orr… - Elife, 2018 - elifesciences.org
The ability of the Chagas disease agent Trypanosoma cruzi to resist extended in vivo
exposure to highly effective trypanocidal compounds prompted us to explore the potential for …

Worldwide control and management of Chagas disease in a new era of globalization: a close look at congenital Trypanosoma cruzi infection

A Abras, C Ballart, A Fernández-Arévalo… - Clinical microbiology …, 2022 - Am Soc Microbiol
Population movements have turned Chagas disease (CD) into a global public health
problem. Despite the successful implementation of subregional initiatives to control vectorial …

[HTML][HTML] WHF IASC roadmap on Chagas disease

LE Echeverría, R Marcus, G Novick, S Sosa-Estani… - Global …, 2020 - ncbi.nlm.nih.gov
Background: Chagas Disease is a neglected tropical disease caused by the protozoan
Trypanosoma cruzi, with some of the most serious manifestations affecting the …

A phase 2, randomized, multicenter, placebo-controlled, proof-of-concept trial of oral fexinidazole in adults with chronic indeterminate Chagas disease

F Torrico, J Gascón, L Ortiz, J Pinto… - Clinical Infectious …, 2023 - academic.oup.com
Background Chagas disease (CD) has significant global health impact, but safe, effective
treatments remain elusive. The nitroimidazole fexinidazole is a potential treatment. Methods …

Antitrypanosomal therapy for chronic Chagas' disease

C Bern - New England Journal of Medicine, 2011 - Mass Medical Soc
Antitrypanosomal Therapy for Chronic Chagas' Disease | New England Journal of Medicine Skip
to main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Short-course combination treatment for experimental chronic Chagas disease

S González, RJ Wall, J Thomas, S Braillard… - Science translational …, 2023 - science.org
Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions of
people in the Americas and across the world, leading to considerable morbidity and …