How cells fuse
Cell–cell fusion remains the least understood type of membrane fusion process. However,
the last few years have brought about major advances in understanding fusion between …
the last few years have brought about major advances in understanding fusion between …
Advances in understanding TKS4 and TKS5: Molecular scaffolds regulating cellular processes from podosome and invadopodium formation to differentiation and …
Scaffold proteins are typically thought of as multi-domain “bridging molecules.” They serve
as crucial regulators of key signaling events by simultaneously binding multiple participants …
as crucial regulators of key signaling events by simultaneously binding multiple participants …
Cooperation between IRTKS and deubiquitinase OTUD4 enhances the SETDB1-mediated H3K9 trimethylation that promotes tumor metastasis via suppressing E …
X Cui, X Shang, J Xie, C Xie, Z Tang, Q Luo, C Wu… - Cancer Letters, 2023 - Elsevier
Elevated expression and genetic aberration of IRTKS, also named as BAIAP2L1, have been
observed in many tumors, especially in tumor progression. however, the molecular and …
observed in many tumors, especially in tumor progression. however, the molecular and …
Heterogeneity and actin cytoskeleton in osteoclast and macrophage multinucleation
J Takito, M Nakamura - International Journal of Molecular Sciences, 2020 - mdpi.com
Osteoclast signatures are determined by two transcriptional programs, the lineage-
determining transcription pathway and the receptor activator of nuclear factor kappa-B …
determining transcription pathway and the receptor activator of nuclear factor kappa-B …
Podosomes: multipurpose organelles?
Thirty years of research have accumulated ample evidence that podosome clusters qualify
as genuine cellular organelles that are being found in more and more cell types. A …
as genuine cellular organelles that are being found in more and more cell types. A …
Generation of Cancer Stem/Initiating Cells by Cell–Cell Fusion
T Dittmar - International Journal of Molecular Sciences, 2022 - mdpi.com
CS/ICs have raised great expectations in cancer research and therapy, as eradication of this
key cancer cell type is expected to lead to a complete cure. Unfortunately, the biology of …
key cancer cell type is expected to lead to a complete cure. Unfortunately, the biology of …
Regulation of osteoclasts by membrane-derived lipid mediators
Osteoclasts are bone-resorbing cells of monocytic origin. An imbalance between bone
formation and resorption can lead to osteoporosis or osteopetrosis. Osteoclastogenesis is …
formation and resorption can lead to osteoporosis or osteopetrosis. Osteoclastogenesis is …
The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins
Implanted medical devices, from artificial heart valves and arthroscopic joints to implantable
sensors, often induce a foreign body response (FBR), a form of chronic inflammation …
sensors, often induce a foreign body response (FBR), a form of chronic inflammation …
[HTML][HTML] Simulation and prediction of membrane fusion dynamics
Z Zheng, S Lü, M Long - Theoretical and Applied Mechanics Letters, 2022 - Elsevier
Membrane fusion is an important process by which biological membranes perform their life
activities. Simulations show that the membrane fusion process happens mainly through …
activities. Simulations show that the membrane fusion process happens mainly through …
Characterization of the intramolecular interactions and regulatory mechanisms of the scaffold protein Tks4
B Merő, K Koprivanacz, A Cserkaszky… - International Journal of …, 2021 - mdpi.com
The scaffold protein Tks4 is a member of the p47phox-related organizer superfamily. It plays
a key role in cell motility by being essential for the formation of podosomes and invadopodia …
a key role in cell motility by being essential for the formation of podosomes and invadopodia …