The toxicity of nanoparticles and their interaction with cells: an in vitro metabolomic perspective

M Awashra, P Młynarz - Nanoscale Advances, 2023 - pubs.rsc.org
Nowadays, nanomaterials (NMs) are widely present in daily life due to their significant
benefits, as demonstrated by their application in many fields such as biomedicine …

Omics approaches for the assessment of biological responses to nanoparticles

Y Abdelkader, L Perez-Davalos, R LeDuc… - Advanced Drug Delivery …, 2023 - Elsevier
Nanotechnology has enabled the development of innovative therapeutics, diagnostics, and
drug delivery systems. Nanoparticles (NPs) can influence gene expression, protein …

Microcellular environmental regulation of silver nanoparticles in cancer therapy: a critical review

G Raja, YK Jang, JS Suh, HS Kim, SH Ahn, TJ Kim - Cancers, 2020 - mdpi.com
Silver nanoparticles (AgNPs) play significant roles in various cancer cells such as functional
heterogeneity, microenvironmental differences, and reversible changes in cell properties …

Mechanistic insights into the biological effects of engineered nanomaterials: A focus on gold nanoparticles

NHA Nguyen, P Falagan-Lotsch - International Journal of Molecular …, 2023 - mdpi.com
Nanotechnology has great potential to significantly advance the biomedical field for the
benefit of human health. However, the limited understanding of nano–bio interactions …

Investigating the effect of Ti3C2 (MXene) nanosheet on human umbilical vein endothelial cells via a combined untargeted and targeted metabolomics approach

D Zhang, W Zheng, X Li, A Li, N Ye, L Zhang, Y Liu… - Carbon, 2021 - Elsevier
Ti 3 C 2 is the first member of two-dimensional (2D) transition metal carbide or carbonitride
(MXene) with excellent photothermal effect in disease treatment on an animal model, which …

Integrating multi-omics and regular analyses identifies the molecular responses of zebrafish brains to graphene oxide: perspectives in environmental criteria

J Sun, Q Zhou, X Hu - Ecotoxicology and environmental safety, 2019 - Elsevier
With the broad application of nanoparticles, nanotoxicology has attracted substantial
attention in environmental science. However, the methods for detecting few and targeted …

Metabolomics profiling to investigate nanomaterial toxicity in vitro and in vivo

A Bannuscher, B Hellack, A Bahl, J Laloy… - …, 2020 - Taylor & Francis
Nanomaterials (NMs) can be produced in plenty of variants posing several challenges for
NM hazard and risk assessment. Metabolomic profiling of NM-treated cells and tissues …

The anti-cancer effects of mitochondrial-targeted triphenylphosphonium–resveratrol conjugate on breast cancer cells

L Jiang, H Yu, C Wang, F He, Z Shi, H Tu, N Ning… - Pharmaceuticals, 2022 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women. Resveratrol, a naturally
occurring phytochemical, shows great promise in developing novel anti-cancer therapies …

Phospholipid-gold nanorods induce energy crisis in mcf-7 cells: Cytotoxicity evaluation using lc-ms-based metabolomics approach

LA Dahabiyeh, NN Mahmoud, MA Al-Natour, L Safo… - Biomolecules, 2021 - mdpi.com
Phospholipid-modified gold nanorods (phospholipid-GNRs) have demonstrated drastic
cytotoxicity towards MCF-7 breast cancer cells compared to polyethylene glycol-coated …

Insight into the effect of a heavy metal mixture on neurological damage in rats through combined serum metabolomic and brain proteomic analyses

J Xie, F Zhou, L Ouyang, Q Li, S Rao, R Su… - Science of The Total …, 2023 - Elsevier
The heavy metals lead (Pb), cadmium (Cd), and mercury (Hg) that cause neurocognitive
impairment have been extensively studied. These elements typically do not exist alone in …