Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Cystathionine-β-synthase: molecular regulation and pharmacological inhibition
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
Mitochondria can cross cell boundaries: An overview of the biological relevance, pathophysiological implications and therapeutic perspectives of intercellular …
Mitochondria are complex intracellular organelles traditionally identified as the
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …
Role of nitric oxide in neurodegeneration: function, regulation, and inhibition
Reactive nitrogen species (RNS) and reactive oxygen species (ROS), collectively known as
reactive oxygen and nitrogen species (RONS), are the products of normal cellular …
reactive oxygen and nitrogen species (RONS), are the products of normal cellular …
[HTML][HTML] The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through# INPST hashtag analysis
Background The development of digital technologies and the evolution of open innovation
approaches have enabled the creation of diverse virtual organizations and enterprises …
approaches have enabled the creation of diverse virtual organizations and enterprises …
Autism spectrum disorder from the womb to adulthood: suggestions for a paradigm shift
C Panisi, FR Guerini, PM Abruzzo, F Balzola… - Journal of personalized …, 2021 - mdpi.com
The wide spectrum of unique needs and strengths of Autism Spectrum Disorders (ASD) is a
challenge for the worldwide healthcare system. With the plethora of information from …
challenge for the worldwide healthcare system. With the plethora of information from …
[HTML][HTML] Natural products, PGC-1α, and Duchenne muscular dystrophy
Peroxisome proliferator-activated receptor γ (PPARγ) is a transcriptional coactivator that
binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators …
binds to a diverse range of transcription factors. PPARγ coactivator 1 (PGC-1) coactivators …
Down syndrome is a metabolic disease: altered insulin signaling mediates peripheral and brain dysfunctions
M Dierssen, M Fructuoso… - Frontiers in …, 2020 - frontiersin.org
Down syndrome (DS) is the most frequent chromosomal abnormality that causes intellectual
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
disability, resulting from the presence of an extra complete or segment of chromosome 21 …
Phytochemicals targeting nitric oxide signaling in neurodegenerative diseases
Neurodegenerative diseases are a set of diseases in which slow and progressive neuronal
loss occurs. Nitric oxide (NO) as a neurotransmitter performs key roles in the stimulation and …
loss occurs. Nitric oxide (NO) as a neurotransmitter performs key roles in the stimulation and …
Metabolic diseases and Down syndrome: how are they linked together?
M Moreau, S Benhaddou, R Dard, S Tolu, R Hamzé… - Biomedicines, 2021 - mdpi.com
Down syndrome is a genetic disorder caused by the presence of a third copy of
chromosome 21, associated with intellectual disabilities. Down syndrome is associated with …
chromosome 21, associated with intellectual disabilities. Down syndrome is associated with …