The relationship between metabolic and inflammatory pathways play a pathogenic role in
various cardiometabolic disorders and is potentially also involved in the pathogenesis of …

Introduction The process of immunoglobulin class switch recombination (CSR) occurs in
secondary lymphoid organs. This highly regulated process is essential for the development …

Background A substantial proportion of common variable immunodeficiency (CVID) patients
has duodenal inflammation of largely unknown etiology. However, because of its histologic …

Introduction Primary immunodeficiencies (PIDs) are a heterogeneous group of disorders,
common variable immunodeficiency disorder (CVID) and X-linked agammaglobulinemia …

Purpose The clinical spectrum of common variable immunodeficiency (CVID) includes
predisposition to infections, autoimmune/inflammatory complications and malignancy. Liver …

Inborn errors of immunity (IEI) are multifaced diseases which can present with a variety of
phenotypes, ranging from infections to autoimmunity, lymphoproliferation, and neoplasms. In …

Background Primary immunodeficiencies are heritable defects in immune system function.
Antibody deficiency is the most common form of primary immunodeficiency in humans, can …

Selective IgA deficiency (sIgAD), common variable immunodeficiency (CVID), and transient
hypogammaglobulinemia of infancy (THI) are the most frequent forms of primary antibody …

Introduction PU. 1-mutated agammaglobulinemia (PU. MA) represents a recently described
autosomal-dominant form of agammaglobulinemia caused by mutation of the SPI1 gene …

Inborn errors of immunity (IEI) can present with infections, autoimmunity, lymphoproliferation,
granulomas, and malignancy. IEIs are due to genetic abnormalities that disrupt normal host …